镁-2 锌-1 钆-0.5 锆合金表面含铜微弧氧化膜的体外降解及抗菌性能
In vitro degradation and antibacterial property of a copper-containing micro-arc oxidation coating on Mg-2Zn-1Gd-0.5Zr alloy.
机构信息
Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China.
Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
出版信息
Colloids Surf B Biointerfaces. 2019 Jul 1;179:77-86. doi: 10.1016/j.colsurfb.2019.03.023. Epub 2019 Mar 16.
Copper (Cu) has a good antibacterial effect and micro-arc oxidation (MAO) coating has good corrosion resistance for magnesium (Mg) alloys. If they are combined together, the coated Mg alloy is expected to have both good corrosion resistance and antibacterial effect. In this work, the degradation, antibacterial property and cytotoxicity of a Cu-containing MAO coating on an extruded Mg-2Zn-1Gd-0.5Zr alloy were systematically studied. The results revealed that the addition of Cu could further improve the degradation resistance of MAO coated alloy. After two weeks immersion, the corrosion rate of Cu + MAO coated alloy was 0.16 mm/y, lower than those of both MAO coated and uncoated alloy. The release of Cu from Cu + MAO coated alloy inhibited the bacterial proliferation. After 12 h co-culture, the antibacterial rate reached 96%. Cytotoxicity test (MG63 cell) showed that Cu + MAO coated alloy had good biocompatibility. The Cu + MAO coating has great potential for application on Mg alloys due to its good corrosion resistance, antibacterial property and good biocompatibility.
铜（Cu）具有良好的抗菌效果，微弧氧化（MAO）涂层对镁（Mg）合金具有良好的耐腐蚀性。如果将它们结合在一起，预计涂层镁合金将同时具有良好的耐腐蚀性和抗菌效果。在这项工作中，系统研究了含铜 MAO 涂层在挤压 Mg-2Zn-1Gd-0.5Zr 合金上的降解、抗菌性能和细胞毒性。结果表明，添加 Cu 可以进一步提高 MAO 涂层合金的耐降解性。浸泡两周后，Cu+MAO 涂层合金的腐蚀速率为 0.16mm/y，低于 MAO 涂层和未涂层合金的腐蚀速率。Cu+MAO 涂层合金中 Cu 的释放抑制了细菌的增殖。共培养 12 小时后，抗菌率达到 96%。细胞毒性试验（MG63 细胞）表明 Cu+MAO 涂层合金具有良好的生物相容性。由于其良好的耐腐蚀性、抗菌性能和良好的生物相容性，Cu+MAO 涂层在镁合金上具有很大的应用潜力。
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