Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Rd West, Fuzhou, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Rd, Shenyang, China.
J Mech Behav Biomed Mater. 2018 May;81:130-141. doi: 10.1016/j.jmbbm.2018.02.026. Epub 2018 Feb 23.
In the study, CoCrWCu alloys with differing Cu content (2, 3, 4 wt%) were prepared by selective laser melting using mixture powders consisting of CoCrW and Cu, aiming at investigating the effect of Cu on the microstructures, mechanical properties, corrosion behavior and cytotoxicity. The SEM observations indicated that the Cu content up to 3 wt% caused the Si-rich precipitates to segregate along grain boundaries and in the grains, and EBSD analysis suggested that the Cu addition decreased the recrystallization degree and increased the grain diameter and fraction of big grains. The tensile tests found that the increasing Cu content led to a decrease of mechanical properties compared with Cu-free CoCrW alloy. The electrochemical tests revealed that the addition of Cu shifted the corrosion potential toward nobler positive, but increased the corrosion current density. Also, a more protective passive film was formed when 2 wt% Cu content was added, but the higher Cu content up to 3 wt% was detrimental to the corrosion resistance. It was noted that there was no cytotoxicity for Cu-bearing CoCrW alloys to MG-63 cell and the cells could spread well on the surfaces of studied alloys. Meanwhile, the Cu-bearing CoCrW alloy exhibited an excellent antibacterial performance against E.coli when Cu content was up to 3 wt%. It is suggested that the feasible fabrication of Cu-bearing CoCrW alloy by SLM using mixed CoCrW and Cu powders is a promising candidate for use in antibacterial oral repair products. This current study also can aid in the further design of antibacterial Cu-containing CoCrW alloying powders.
在这项研究中，使用由 CoCrW 和 Cu 组成的混合粉末通过选择性激光熔化制备了具有不同 Cu 含量（2、3、4 wt%）的 CoCrWCu 合金，旨在研究 Cu 对微观结构、力学性能、腐蚀行为和细胞毒性的影响。SEM 观察表明，Cu 含量高达 3 wt% 导致富 Si 析出物沿晶界和晶粒内偏析，EBSD 分析表明，Cu 的添加降低了再结晶程度，增加了晶粒直径和大晶粒的分数。拉伸试验发现，与不含 Cu 的 CoCrW 合金相比，随着 Cu 含量的增加，力学性能下降。电化学测试表明，添加 Cu 使腐蚀电位向更正的方向移动，但增加了腐蚀电流密度。此外，当添加 2 wt% Cu 时形成了更具保护性的钝化膜，但更高的 Cu 含量（高达 3 wt%）不利于耐腐蚀性。值得注意的是，含 Cu 的 CoCrW 合金对 MG-63 细胞没有细胞毒性，细胞可以在研究合金表面很好地扩展。同时，当 Cu 含量高达 3 wt% 时，含 Cu 的 CoCrW 合金对大肠杆菌表现出优异的抗菌性能。建议使用混合的 CoCrW 和 Cu 粉末通过 SLM 制造含 Cu 的 CoCrW 合金是一种有前途的抗菌口腔修复产品用材料。本研究还可以帮助进一步设计抗菌含 Cu CoCrW 合金粉末。
