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从. 中分离和生物测定一种新的端酮 A。

Isolation and Bioassay of a New Terminalone A from .

机构信息

Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan.

Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

出版信息

Molecules. 2023 Jan 19;28(3):1015. doi: 10.3390/molecules28031015.

DOI:10.3390/molecules28031015
PMID:36770680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9919985/
Abstract

possesses significant cardioprotective, antidiabetic and antioxidant properties as these properties are described in Ayurveda. In the present study, three flavonoids were isolated through the separation and chromatographic purification of the whole plant material of . Spectroscopic characterization identified one of them as a new flavonoid " A ()" and two known flavonoids i.e., () and (). The bioactivity studies showed considerable antibacterial and antioxidant (DPPH radical scavenging) potential for all the three compounds - where the compound showed strong antibacterial and antioxidant activity.

摘要

它具有显著的心脏保护、抗糖尿病和抗氧化特性,正如 Ayurveda 中所描述的那样。在本研究中,通过分离和色谱纯化 的全植物材料,分离出三种类黄酮。光谱特征鉴定出其中一种为新的类黄酮“ A()”和两种已知的类黄酮,即()和()。生物活性研究表明,所有三种化合物都具有相当强的抗菌和抗氧化(DPPH 自由基清除)活性 - 其中化合物显示出很强的抗菌和抗氧化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c438/9919985/0a379ed2bba1/molecules-28-01015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c438/9919985/e2c2ff23cb00/molecules-28-01015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c438/9919985/c4495d16170e/molecules-28-01015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c438/9919985/0a379ed2bba1/molecules-28-01015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c438/9919985/e2c2ff23cb00/molecules-28-01015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c438/9919985/c4495d16170e/molecules-28-01015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c438/9919985/0a379ed2bba1/molecules-28-01015-g003.jpg

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本文引用的文献

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Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface.
氧化铁纳米颗粒在调节纳米颗粒-细菌界面时的抗菌活性。
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Terminalia arjuna in coronary artery disease: ethnopharmacology, pre-clinical, clinical & safety evaluation.没食子诃子在冠状动脉疾病中的应用:民族药理学、临床前、临床和安全性评价。
J Ethnopharmacol. 2014 Sep 11;155(2):1029-45. doi: 10.1016/j.jep.2014.06.056. Epub 2014 Jul 8.
7
Activity-guided isolation of antioxidants from the leaves of Terminalia arjuna.从诃子叶中活性导向分离抗氧化剂。
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8
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Fitoterapia. 2009 Sep;80(6):369-73. doi: 10.1016/j.fitote.2009.05.006. Epub 2009 May 14.
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