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铁蛋白包覆的超顺磁性氧化铁纳米颗粒作为新型癌细胞靶向磁性纳米载体。

Ferritin-Coated SPIONs as New Cancer Cell Targeted Magnetic Nanocarrier.

机构信息

Department of Physics and Chemistry-Emilio Segrè, University of Palermo, 90128 Palermo, Italy.

Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, 90123 Palermo, Italy.

出版信息

Molecules. 2023 Jan 24;28(3):1163. doi: 10.3390/molecules28031163.

DOI:10.3390/molecules28031163
PMID:36770830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9919024/
Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) may act as an excellent theragnostic tool if properly coated and stabilized in a biological environment, even more, if they have targeting properties towards a specific cellular target. Humanized Ferritin (HumAfFt) is an engineered ferritin characterized by the peculiar salt-triggered assembly-disassembly of the hyperthermophile ferritin and is successfully endowed with the human H homopolymer recognition sequence by the transferrin receptor (TfR1 or CD71), overexpressed in many cancer cells in response to the increased demand of iron. For this reason, HumAfFt was successfully used in this study as a coating material for 10 nm SPIONs, in order to produce a new magnetic nanocarrier able to discriminate cancer cells from normal cells and maintain the potential theragnostic properties of SPIONs. HumAfFt-SPIONs were exhaustively characterized in terms of size, morphology, composition, and cytotoxicity. The preferential uptake capacity of cancer cells toward HumAfFt-SPIONs was demonstrated in vitro on human breast adenocarcinoma (MCF7) versus normal human dermal fibroblast (NHDF) cell lines.

摘要

超顺磁氧化铁纳米粒子 (SPIONs) 如果在生物环境中得到适当的包覆和稳定，甚至具有针对特定细胞靶标的靶向特性，那么它们可能成为一种出色的治疗诊断工具。人源化铁蛋白 (HumAfFt) 是一种经过工程改造的铁蛋白，其特点是超嗜热铁蛋白的盐触发组装-拆卸，并且通过转铁蛋白受体 (TfR1 或 CD71) 成功赋予了人 H 同源聚合物识别序列，在许多癌细胞中过度表达，以满足铁的增加需求。出于这个原因，HumAfFt 在这项研究中被成功用作 10nm SPIONs 的包覆材料，以生产一种新的磁性纳米载体，能够区分癌细胞和正常细胞，并保持 SPIONs 的潜在治疗诊断特性。HumAfFt-SPIONs 在尺寸、形态、组成和细胞毒性方面进行了详尽的表征。在体外，人乳腺癌腺癌细胞 (MCF7) 与正常人类真皮成纤维细胞 (NHDF) 系之间证明了癌细胞对 HumAfFt-SPIONs 的优先摄取能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/9f7725ef293e/molecules-28-01163-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/3129d2ae6dbe/molecules-28-01163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/26ec1a5cc9f0/molecules-28-01163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/631835caf47f/molecules-28-01163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/c19c0e0f0d63/molecules-28-01163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/c04283d8d3b4/molecules-28-01163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/551f56bb8ae4/molecules-28-01163-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/f0120f54d022/molecules-28-01163-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/9f7725ef293e/molecules-28-01163-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/3129d2ae6dbe/molecules-28-01163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/26ec1a5cc9f0/molecules-28-01163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/631835caf47f/molecules-28-01163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/c19c0e0f0d63/molecules-28-01163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/c04283d8d3b4/molecules-28-01163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/551f56bb8ae4/molecules-28-01163-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/f0120f54d022/molecules-28-01163-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dc7/9919024/9f7725ef293e/molecules-28-01163-g008.jpg

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[2]
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[6]
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[7]
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[9]
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引用本文的文献

[1]
Magnetic and MRI Contrast Properties of HumAfFt-SPIONs: Investigating Superparamagnetic Behavior and Enhanced T-Weighted Imaging Performance.

Int J Mol Sci. 2025-4-9

[2]
Breaking barriers: Smart vaccine platforms for cancer immunomodulation.

Cancer Commun (Lond). 2025-5

[3]
Challenges in Exploiting Human H Ferritin Nanoparticles for Drug Delivery: Navigating Physiological Constraints.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024

[4]
Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides.

Front Mol Biosci. 2024-1-5

[5]
Effect of Highly Hydrophilic Superparamagnetic Iron Oxide Nanoparticles on Macrophage Function and Survival.

J Funct Biomater. 2023-10-12

本文引用的文献

[1]
In vivo efficacy of verteporfin loaded gold nanorods for combined photothermal/photodynamic colon cancer therapy.

Int J Pharm. 2022-9-25

[2]
Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells.

Sci Rep. 2019-8-13

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Int J Pharm. 2018-12-6

[4]
SPIONs embedded in polyamino acid nanogels to synergistically treat tumor microenvironment and breast cancer cells.

Int J Pharm. 2018-11-17

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Potential use of superparamagnetic iron oxide nanoparticles for in vitro and in vivo bioimaging of human myoblasts.

Sci Rep. 2018-2-27

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Nanoscale. 2017-1-5

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Nanomedicine (Lond). 2016-11-23

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Biochim Biophys Acta Gen Subj. 2016-10-15

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J Colloid Interface Sci. 2016-4-15

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The unique self-assembly/disassembly property of Archaeoglobus fulgidus ferritin and its implications on molecular release from the protein cage.

Biochim Biophys Acta. 2015-12

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