魔芋葡甘聚糖对 2 型糖尿病患者的影响：Meta 分析。

Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis.

机构信息

Department of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Key Laboratory of Cancer FSMP for State Market Regulation, Beijing 100038, China.

出版信息

Nutrients. 2023 Jan 24;15(3):601. doi: 10.3390/nu15030601.

DOI:10.3390/nu15030601

PMID:36771306

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9919128/

Abstract

The hypoglycemic and lipid-lowering effects of glucomannan are widely known, and it is a potential effective treatment for type II diabetes. In this study, we evaluated the effects of glucomannan supplementation on blood-lipid-related indicators, blood-glucose-related indicators, blood pressure (BP), and body weight (BW) in patients suffering from type II diabetes. We searched databases including PubMed, Cochrane, the comprehensive biomedical research database (Embase), Web of Science, and China National Knowledge Infrastructure (CNKI) for literature on glucomannan and type II diabetes. Six randomized controlled trials (RCTs) were eligible ( = 440 participants) to be included in our analysis. Glucomannan not only reduced the total cholesterol (TC) (MD -0.38 [95% CI: -0.61, -0.15], = 0.001) and low-density lipoprotein (LDL) levels (MD -0.35 [95% CI: -0.52, -0.17], < 0.0001) compared with the control group, but also reduced the fasting blood glucose (FBG) (MD -1.08 [95% CI: -1.65, -0.50], = 0.0002), 2 h postprandial blood glucose (P2hBG) (MD -1.92 [95% CI: -3.19, -0.65], = 0.003), fasting insulin (FINS) (MD -1.59 [95% CI: -2.69, -0.50], = 0.004), and serum fructosamine (SFRA) levels (SMD -1.19 [95% CI: -1.74, -0.64], < 0.0001). Our analysis indicates that glucomannan is an effective nutritional intervention for type II diabetes.

摘要

魔芋的降血糖和降血脂作用已广为人知，它是治疗 2 型糖尿病的一种有潜力的有效方法。在这项研究中，我们评估了魔芋补充剂对 2 型糖尿病患者的血脂相关指标、血糖相关指标、血压（BP）和体重（BW）的影响。我们检索了包括 PubMed、Cochrane、全面生物医学研究数据库（Embase）、Web of Science 和中国国家知识基础设施（CNKI）在内的数据库，以获取关于魔芋和 2 型糖尿病的文献。共有 6 项随机对照试验（RCTs）符合纳入标准（n = 440 名参与者）。与对照组相比，魔芋不仅降低了总胆固醇（TC）（MD -0.38 [95% CI: -0.61, -0.15]， = 0.001）和低密度脂蛋白（LDL）水平（MD -0.35 [95% CI: -0.52, -0.17]， < 0.0001），还降低了空腹血糖（FBG）（MD -1.08 [95% CI: -1.65, -0.50]， = 0.0002）、餐后 2 小时血糖（P2hBG）（MD -1.92 [95% CI: -3.19, -0.65]， = 0.003）、空腹胰岛素（FINS）（MD -1.59 [95% CI: -2.69, -0.50]， = 0.004）和血清果糖胺（SFRA）水平（SMD -1.19 [95% CI: -1.74, -0.64]， < 0.0001）。我们的分析表明，魔芋是 2 型糖尿病的一种有效营养干预措施。