Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410008, China.
Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha 410078, China.
Nutrients. 2023 Jan 24;15(3):604. doi: 10.3390/nu15030604.
Evidence indicates that certain healthy lifestyle factors are associated with non-alcoholic fatty liver disease (NAFLD). However, little is known about the effect of combined healthy lifestyle factors.
To assess the association of combined healthy lifestyle factors with the incidence of NAFLD.
This cohort study was conducted in Changsha, Hunan Province, China. The healthy lifestyles factors studied were not being a current smoker, having a healthy diet, engaging in physical activity, having a normal body mass index (BMI) and engaging in non-sedentary behavior. NAFLD was diagnosed based on abdominal ultrasonography. Logistic regression models were conducted to investigate the associations being studied.
Of the 5411 participants, 1280 participants had NAFLD, with a prevalence of 23.7% at baseline. The incidence of NAFLD among participants without NAFLD at baseline was found to be 7.2% over a mean follow-up of 1.1 years. Compared with participants with 0-1 low-risk factors, the OR of NAFLD was 0.50 (95% CI: 0.29-0.82, = 0.008) for those with at least 4 low-risk factors. Similar associations were observed in subgroup analyses and sensitivity analyses.
This study suggests that a combined healthy lifestyle pattern may considerably decrease the risk of NAFLD in Chinese government employees.
有证据表明，某些健康的生活方式因素与非酒精性脂肪性肝病（NAFLD）有关。然而，对于综合健康生活方式因素的影响知之甚少。
评估综合健康生活方式因素与 NAFLD 发生率之间的关系。
本队列研究在中国湖南省长沙市进行。所研究的健康生活方式因素包括不吸烟、健康饮食、身体活动、正常体重指数（BMI）和非久坐行为。NAFLD 基于腹部超声诊断。采用逻辑回归模型分析研究关联。
在 5411 名参与者中，有 1280 名患有 NAFLD，基线时患病率为 23.7%。在基线时没有 NAFLD 的参与者中，NAFLD 的发生率在平均 1.1 年的随访中为 7.2%。与具有 0-1 个低风险因素的参与者相比，至少有 4 个低风险因素的参与者的 NAFLD 的 OR 为 0.50（95%CI：0.29-0.82，=0.008）。亚组分析和敏感性分析也观察到了类似的关联。
本研究表明，综合健康的生活方式模式可能显著降低中国政府雇员患 NAFLD 的风险。
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