Souetre E, Salvati E, Wehr T A, Sack D A, Krebs B, Darcourt G
Clinique de Psychiatrie et de Psychologie Medicale, Hôpital Pasteur, Nice, France.
Am J Psychiatry. 1988 Sep;145(9):1133-7. doi: 10.1176/ajp.145.9.1133.
The 24-hour patterns of body temperature and plasma thyrotropin (TSH) were measured in eight bipolar patients in both depressed and recovered (after 3 weeks of treatment) states and in eight normal control subjects. Clear circadian patterns were detected for both temperature and TSH. Nocturnal body temperature was increased and the nocturnal surge of TSH was blunted during depression; these abnormalities were corrected after recovery. The inverse relationship between changes in body temperature and TSH levels at night suggests that changes in thermoregulation may be responsible for the neuroendocrine disturbance and may play a role in the pathophysiology of depression.
对8名双相情感障碍患者在抑郁状态和康复状态（治疗3周后）以及8名正常对照者测量了24小时体温和血浆促甲状腺激素（TSH）模式。体温和TSH均检测到明显的昼夜节律模式。抑郁期间夜间体温升高，TSH夜间高峰减弱；康复后这些异常得到纠正。夜间体温变化与TSH水平之间的负相关表明，体温调节变化可能是神经内分泌紊乱的原因，可能在抑郁症的病理生理学中起作用。
