Department of Clinical Laboratory, 74540The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Cancer Control. 2023 Jan-Dec;30:10732748231155700. doi: 10.1177/10732748231155700.
Renal clear cell carcinoma (ccRCC) and the tumor microenvironment (TME) influence each other, leading to the tumor microenvironment that can guide the corresponding treatment. With the deepening of research, some treatment options have achieved good results, such as tyrosine kinase inhibitors, immune checkpoint inhibitors, and so on. As the link between TME and malignancy is constantly discovered, more targeted studies on different components of TME are increasing, and this targeted therapy is a new method for treating ccRCC, and also a current research hotspot. This review summarizes the characteristics of the ccRCC tumor microenvironment, the outcomes of different treatments, and some potential targets.
肾透明细胞癌 (ccRCC) 和肿瘤微环境 (TME) 相互影响，导致肿瘤微环境可以指导相应的治疗。随着研究的深入，一些治疗选择已经取得了良好的效果，如酪氨酸激酶抑制剂、免疫检查点抑制剂等。随着 TME 与恶性肿瘤之间的联系不断被发现，对 TME 不同成分的更有针对性的研究正在增加，这种靶向治疗是治疗 ccRCC 的一种新方法，也是当前的研究热点。本文综述了 ccRCC 肿瘤微环境的特征、不同治疗方法的结果以及一些潜在的靶点。
