2,4-二硝基氯苯诱导的小鼠模型中热水提取物的抗变态反应活性。
Anti-Atopic Activities of Hot Water Extracts in 2,4-Dinitrochlorobezene-Induced Mouse Models.
机构信息
Department of Food Science and Technology/Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea.
Institute of Fisheries Sciences, Pukyong National University, Busan 48513, Republic of Korea.
出版信息
J Microbiol Biotechnol. 2023 Mar 28;33(3):363-370. doi: 10.4014/jmb.2211.11007. Epub 2023 Jan 13.
Atopic dermatitis (AD) is a chronic inflammation associated with skin hypersensitivity caused by environmental factors. The objent of this study was to assess the hot water extracts of (SHHWE) on AD. AD was induced by spreading 2,4-dinitrochlorobenzene (DNCB) on the BALB/c mice. The efficacy of SHHWE was tested by observing the immunoglobulin E (IgE), cytokine, skin clinical severity score and cytokine secretions in concanavalin A (Con A)-stimulated splenocytes. The levels of interleukine (IL)-4, IL-5 and IgE, the pro-inflammatory cytokines that are closely related, were notably suppressed in a does-dependent manner by SHHWE, whereas the level of interferon γ (IFN-γ), the atopy-related Th1 cytokine inhibiting the production of Th2 cytokines, was increased. Therefore, these results show that SHHWE has a potent anti-inhibitory effect on AD and is highly valuable for cosmetic development.
特应性皮炎（AD）是一种由环境因素引起的皮肤过敏相关的慢性炎症。本研究旨在评估（SHHWE）对 AD 的热水提取物的影响。通过在 BALB/c 小鼠上涂抹 2,4-二硝基氯苯（DNCB）来诱导 AD。通过观察免疫球蛋白 E（IgE）、细胞因子、皮肤临床严重程度评分和刀豆蛋白 A（Con A）刺激的脾细胞中的细胞因子分泌来测试 SHHWE 的功效。SHHWE 以剂量依赖的方式显著抑制与 AD 密切相关的促炎细胞因子白细胞介素（IL）-4、IL-5 和 IgE 的水平，而 Th1 细胞因子干扰素γ（IFN-γ）的水平则增加，IFN-γ 抑制 Th2 细胞因子的产生。因此，这些结果表明 SHHWE 对 AD 具有强大的抑制作用，对化妆品的开发具有很高的价值。
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