Choudhary Priyanka, Kumari Kamlesh, Sharma Devendra, Kumar Sahil, Krishnan Venkata
School of Chemical Sciences and Advanced Materials Research Center, Indian Institute of Technology Mandi, Mandi 175075, Himachal Pradesh, India.
ACS Appl Mater Interfaces. 2023 Feb 12. doi: 10.1021/acsami.2c21545.
One of the important industrial processes commonly employed in the pharmaceutical, explosive, and plastic manufacturing industries is -hydroxylation of arylboronic acids. In this work, a straightforward, metal-free methodology for the synthesis of phenols from arylboronic acids has been demonstrated using hydroxyl functionalized boron nitride (BN-OH) nanosheets. The functionalized hydroxyl groups on the BN nanosheets act as the active sites for the hydroxylation reaction to take place. The detailed optimization of reaction parameters was done in order to attain high catalytic efficiency, and the reactions were conducted in water, which eliminates the use of toxic solvents. The as-synthesized catalysts exhibited excellent recyclability and reusability in addition to high product yields and good turnover numbers. The green metrics parameters were also evaluated for the model reaction to examine the sustainable nature of the developed protocol. The use of BN-OH catalysts for the -hydroxylation reactions under base-free and metal-free conditions using environmentally benign solvents is utmost desired for industrial processes and can pave a way toward sustainable organic catalysis.
芳基硼酸的羟基化是制药、炸药和塑料制造行业常用的重要工业过程之一。在这项工作中，已证明使用羟基官能化的氮化硼（BN-OH）纳米片，可从芳基硼酸合成苯酚，这是一种直接的无金属方法。BN纳米片上的官能化羟基充当发生羟基化反应的活性位点。为了获得高催化效率，对反应参数进行了详细优化，反应在水中进行，从而避免了使用有毒溶剂。除了高产物收率和良好的周转数外，所合成的催化剂还表现出优异的可回收性和可重复使用性。还对模型反应的绿色指标参数进行了评估，以检验所开发方案的可持续性。在无碱和无金属条件下，使用环境友好型溶剂，将BN-OH催化剂用于羟基化反应，这是工业过程最需要的，可为可持续有机催化铺平道路。
