Dawwas Ghadeer K, Jajeh Hamzeh, Shan Mingyang, Naegeli April N, Hunter Theresa, Lewis James D
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Center for Pharmacoepidemiology Research and Training, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Crohns Colitis 360. 2021 Jul 8;3(3):otab046. doi: 10.1093/crocol/otab046. eCollection 2021 Jul.
In patients with ulcerative colitis (UC) and Crohn's disease (CD), this research examined the following: prevalence of fecal urgency (hereafter urgency), association of urgency with inflammatory bowel disease (IBD) symptoms and fecal calprotectin, and association between well-being and urgency.
In this cross-sectional study from the Study of a Prospective Adult Research Cohort with IBD, urgency was categorized as none, mild, and moderate-severe. We examined the prevalence of urgency, association of urgency with IBD symptoms and fecal calprotectin (in a subset) using multinomial logistic regression, and association of well-being (not feeling well vs generally well) with urgency using logistic regression.
Among 576 UC patients, 31.4% reported mild and 28.1% moderate-severe urgency. Among 1330 CD patients, 33.8% reported mild and 31.4% moderate-severe urgency. In UC, moderate-severe urgency was associated with: increased average bowel movements/day [odds ratio (OR) 1.23; 95% confidence interval: 1.09, 1.23], increased stool frequency relative to normal (OR, 9.95; 95% CI: 3.21, 30.87), rectal bleeding (OR, 3.36; 95% CI: 1.79, 6.34), moderate-severe abdominal pain (OR, 17.5; 95% CI: 5.38, 56.89), and calprotectin ≥ 250 μg/g (OR, 4.36; 95% CI: 1.50, 12.66). In CD, moderate-severe urgency was associated with: increased average bowel movements/day (OR, 1.23; 95% CI: 1.14, 1.34), increased stool frequency relative to normal (OR, 7.57; 95% CI: 3.30, 17.34), rectal bleeding (OR, 1.77; 95% CI: 1.13, 2.78), and moderate-severe abdominal pain (OR, 7.52; 95% CI: 4.31, 13.14). Reduced well-being was associated with moderate-severe urgency in both UC (OR, 4.20; 95% CI: 1.69, 20.40) and CD patients (OR, 2.52; 95% CI: 1.51, 4.22).
Urgency was common and associated with symptoms and biomarkers suggesting active IBD and reduced well-being.
在溃疡性结肠炎（UC）和克罗恩病（CD）患者中，本研究调查了以下内容：粪便急迫感（以下简称急迫感）的患病率、急迫感与炎症性肠病（IBD）症状及粪便钙卫蛋白的关联，以及健康状况与急迫感之间的关联。
在这项来自IBD前瞻性成人研究队列的横断面研究中，急迫感被分为无、轻度和中重度。我们使用多项逻辑回归分析了急迫感的患病率、急迫感与IBD症状及粪便钙卫蛋白（在一个子集中）的关联，并使用逻辑回归分析了健康状况（感觉不适与总体良好）与急迫感的关联。
在576例UC患者中，31.4%报告有轻度急迫感，28.1%报告有中重度急迫感。在1330例CD患者中，33.8%报告有轻度急迫感，31.4%报告有中重度急迫感。在UC中，中重度急迫感与以下因素相关：每日平均排便次数增加[比值比（OR）1.23；95%置信区间：1.09，1.23]、相对于正常情况的排便频率增加（OR，9.95；95%置信区间：3.21，30.87）、直肠出血（OR，3.36；95%置信区间：1.79，6.34）、中重度腹痛（OR，17.5；95%置信区间：5.38，56.89）以及钙卫蛋白≥250μg/g（OR，4.36；95%置信区间：1.50，12.66）。在CD中，中重度急迫感与以下因素相关：每日平均排便次数增加（OR，1.23；95%置信区间：1.14，1.34）、相对于正常情况的排便频率增加（OR，7.57；95%置信区间：3.30，17.34）、直肠出血（OR，1.77；95%置信区间：1.13，2.78）以及中重度腹痛（OR，7.52；95%置信区间：4.31，13.14）。在UC（OR，4.20；95%置信区间：1.69，20.40）和CD患者（OR，2.52；95%置信区间：1.51，4.22）中，健康状况下降均与中重度急迫感相关。
急迫感很常见，且与提示IBD活动及健康状况下降的症状和生物标志物相关。
Zotero 插件
