Tavares Carolina Santos Souza, Gomes Dos Santos Oliveira Sheila Jaqueline, de Gois-Santos Vanessa Tavares, Vaez Andreia Centenaro, de Menezes Max Oliveira, Santos Hudson P, Santos Victor Santana, Martins-Filho Paulo Ricardo
Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Brazil.
Investigative Pathology Laboratory, Federal University of Sergipe, Hospital Universitário, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju CEP: 49060-100, Brazil.
Lancet Reg Health Am. 2021 Dec 1;7:100127. doi: 10.1016/j.lana.2021.100127. eCollection 2022 Mar.
Congenital syphilis is an important public health problem in low- and middle-income countries. Poor neonatal health outcomes associated with the disease may lead to maternal psychological distress and feelings of helplessness. This study aimed to evaluate the quality of life, anxiety levels, depressive symptoms, and sexual function in mothers of neonates with congenital syphilis in the Northeast of Brazil.
This cohort study compared patient-centered outcomes between mothers of neonates with congenital syphilis and mothers of healthy neonates during the first three months of the postpartum period. The study was conducted in Sergipe state, Northeast Brazil, a region with one of the highest rates of congenital syphilis (14·1 cases per 1000 live births). Quality of life, depressive symptoms, anxiety levels, and sexual function were evaluated by using the World Health Organization Quality of Live - shortened version (WHOQoL-BREF) instrument, Beck Depression Inventory, Spielberger State-Trait Anxiety Inventory, and Female Sexual Function Index, respectively. Unadjusted differences between groups were anayzed by using the Mann-Whitney test. Glass's delta with 95% confidence interval (CI) was used to measure the effect size.
Sixty-three women were included in each group. During the in-hospital stay, mothers of neonates with congenital syphilis had lower scores for overall quality of life ( < 0·001; large effect size: -0·559 [95% CI -0·683 to -0·405]) and higher levels of anxiety ( < 0·001; large effect size: 0·558 [95% CI 0·403 to 0·681]) and depressive symptoms ( < 0·001; large effect size: 0·561 [95% CI 0·407 to 0·684]) than mothers of healthy neonates. Three months after childbirth, we found persistent depressive symptoms ( = 0·021; small effect size: 0·239 [95% CI 0·041 to 0·419]) and low overall sexual function ( = 0·041; small effect size: -0·211 [95% CI -0·394 to -0·012]) among mothers of neonates with congenital syphilis compared to the control group.
Mothers of neonates with congenital syphilis present poorer quality of life, mental health, and sexual function compared to mothers of healthy neonates.
Brazilian Federal Agency for Coordination of Improvement of Higher Education Personnel (CAPES).
先天性梅毒在低收入和中等收入国家是一个重要的公共卫生问题。与该疾病相关的新生儿健康状况不佳可能会导致母亲出现心理困扰和无助感。本研究旨在评估巴西东北部患有先天性梅毒的新生儿母亲的生活质量、焦虑水平、抑郁症状和性功能。
这项队列研究比较了产后头三个月内患有先天性梅毒的新生儿母亲与健康新生儿母亲以患者为中心的结局。该研究在巴西东北部的塞尔希培州进行，该地区是先天性梅毒发病率最高的地区之一（每1000例活产中有14.1例）。分别使用世界卫生组织生活质量简表（WHOQoL-BREF）、贝克抑郁量表、斯皮尔伯格状态-特质焦虑量表和女性性功能指数来评估生活质量、抑郁症状、焦虑水平和性功能。使用曼-惠特尼检验分析组间未调整的差异。采用95%置信区间（CI）的格拉斯δ来衡量效应大小。
每组纳入63名女性。在住院期间，患有先天性梅毒的新生儿母亲的总体生活质量得分较低（<0.001；大效应大小：-0.559 [95%CI -0.683至-0.405]），焦虑水平（<0.001；大效应大小：0.558 [95%CI 0.403至0.681]）和抑郁症状（<0.001；大效应大小：0.561 [95%CI 0.407至0.684]）高于健康新生儿母亲。分娩后三个月，我们发现与对照组相比，患有先天性梅毒的新生儿母亲存在持续的抑郁症状（=0.021；小效应大小：0.239 [95%CI 0.041至0.419]）和较低的总体性功能（=0.041；小效应大小：-0.211 [95%CI -0.394至-0.012]）。
与健康新生儿母亲相比，患有先天性梅毒的新生儿母亲的生活质量、心理健康和性功能较差。
巴西高等教育人员协调联邦机构（CAPES）。
