Plouin P F, Degoulet P, Menard D, Drouet J, Menard J
Eur J Nucl Med. 1978 Jul 1;3(3):183-6. doi: 10.1007/BF00256641.
Labeled IgG was evaluated versus labeled albumin for measurement of plasma volume, to see whether it would give a smaller initial dilution volume (indicating a smaller premixing extravascular loss of label) and a smaller difference between initial dilution volume and dilution volume at time 10 min (indicating a negligible extravascular loss in the first 10 min after mixing). IgG was found to have a lower transcapillary escape rate than albumin (P less than 0.01) in eight normal volunteers and in eight hypertensive subjects, hypertension being associated with an increased transcapillary escape of both proteins. Despite this, the dilution volumes obtained were indistinguishable and the need for a correction through a retropolation procedure was the same with both proteins. Albumin and IgG dilution volumes were highly correlated in 21 subjects (r=0.977) so that use of labeled IgG is a proper alternative to use of labeled albumin for plasma volume determination. However, since IgG brings no consistent advantage, labeled albumin remains the best available tracer for that purpose.
对标记的免疫球蛋白（IgG）和标记的白蛋白进行评估，以测量血浆容量，观察其是否会产生较小的初始稀释体积（表明标记物在血管外预混合损失较小）以及初始稀释体积与10分钟时稀释体积之间的较小差异（表明混合后最初10分钟内血管外损失可忽略不计）。在8名正常志愿者和8名高血压患者中发现，IgG的毛细血管逃逸率低于白蛋白（P<0.01），高血压与两种蛋白质的毛细血管逃逸增加有关。尽管如此，获得的稀释体积并无差异，两种蛋白质通过反向推算程序进行校正的需求相同。在21名受试者中，白蛋白和IgG的稀释体积高度相关（r=0.977），因此使用标记的IgG是用于血浆容量测定的标记白蛋白的合适替代方法。然而，由于IgG没有一致的优势，标记白蛋白仍然是用于该目的的最佳可用示踪剂。
