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[法国武装部队生物医学研究所(IRBA)与基于废水的流行病学:在武装部队中的适用性和相关性]

[The French Armed Forces Biomedical Research Institute (IRBA) and wastewater-based epidemiology: Applicability and relevance in armed forces].

作者信息

Boni M, Gorgé O, Mullot J-U, Wurtzer S, Moulin L, Maday Y, Obépine Gis, Canini F, Chantre M, Teyssou R, Maréchal V, Janvier F, Tournier J-N

机构信息

Institut de recherche biomédicale des armées, 1, place Valérie-André, 91220 Brétigny-sur-Orge, France.

Groupement d'intérêt scientifique Obépine, France.

出版信息

Bull Acad Natl Med. 2022 Oct;206(8):1011-1021. doi: 10.1016/j.banm.2022.04.025. Epub 2022 Aug 17.

Abstract

The French Armed Forces Biomedical Research Institute (IRBA) deeply involved in research on SARS-COV-2, participated in the creation of the Obépine sentinel network in charge of detecting, qualifying and quantifying the virus genome in wastewater in France. During this pandemic, wastewater-based epidemiology has proven to be a first class public health tool for assessing viral dynamics in populations and environment. Obépine has also conducted research demonstrating the low infectivity of faeces and wastewater and allowed for early detection of epidemic waves linked to new variants. The IRBA has adapted this powerful tool to the monitoring of viral infections on board the aircraft carrier Charles-de-Gaulle in order to get an operational system for anticipation after the first local outbreak in 2020. The presence of this surveillance and anticipation tool has allowed a better management of SARS-CoV-2 contingent introductions on board during stopovers or crewmembers entries. The combination of a mandatory vaccination protocol and the surveillance of viral circulation in black waters has made it possible to identify and locate cases, and thus to continue the operational mission in the COVID-19 environment while limiting the spread and preserving the health of the crew. This innovative tool can easily be redirected to the search for any other pathogens in blackwater or even, in the long term, to ensure health surveillance of any military establishment, at sea or on land, in France or on overseas bases.

摘要

法国武装部队生物医学研究所(IRBA)深度参与了对SARS-CoV-2的研究,参与创建了Obépine哨兵网络,该网络负责在法国检测、鉴定和量化废水中的病毒基因组。在这场大流行期间,基于废水的流行病学已被证明是评估人群和环境中病毒动态的一流公共卫生工具。Obépine还开展了研究,证明粪便和废水的传染性较低,并能够早期发现与新变种相关的疫情波。IRBA对这一强大工具进行了调整,用于监测戴高乐号航空母舰上的病毒感染情况,以便在2020年首次出现局部疫情后建立一个预警操作系统。这种监测和预警工具的存在使得在中途停留或船员登舰期间能够更好地管理SARS-CoV-2在舰上的意外传入情况。强制接种疫苗方案与对黑水(粪便)中病毒传播的监测相结合,使得能够识别和定位病例,从而在COVID-19环境下继续执行任务,同时限制传播并保护船员健康。这种创新工具可以轻松地重新用于在黑水中寻找任何其他病原体,甚至从长远来看,用于确保对法国境内或海外基地的任何海上或陆上军事设施进行健康监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b5/9906811/935cc18e715d/gr1_lrg.jpg

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