Satarzadeh Naghmeh, Sadeghi Dousari Amin, Amirheidari Bagher, Shakibaie Mojtaba, Ramezani Sarbandi Amin, Forootanfar Hamid
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Department of Microbiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
3 Biotech. 2023 Mar;13(3):79. doi: 10.1007/s13205-023-03476-4. Epub 2023 Feb 9.
Evidence shows that nanoparticles exert lower toxicity, improved targeting, and enhanced bioactivity, and provide versatile means to control the release profile of the encapsulated moiety. Among different NPs, inorganic nanoparticles (Ag, Au, Ce, Fe, Se, Te, Zn, etc.) possess a considerable place owing to their unique bioactivities in nanoforms. Selenium, an essential trace element, played a vital role in the growth and development of living organisms. It has attracted great interest as a therapeutic factor without significant adverse effects in medicine at recommended dose. Selenium nanoparticles can be fabricated by physical, biological, and chemical approaches. The biosynthesis of nanoparticles is shown an advance compared to other procedures, because it is environmentally friendly, relatively reproducible, easily accessible, biodegradable, and often results in more stable materials. The effect of size, shape, and synthesis methods on their applications in biological systems investigated by several studies. This review focused on the procedures for the synthesis of selenium nanoparticles, in particular the biogenesis of selenium nanoparticles and their biomedical characteristics, such as antibacterial, antiviral, antifungal, and antiparasitic properties. Eventually, a comprehensive future perspective of selenium nanoparticles was also presented.
证据表明，纳米颗粒具有较低的毒性、更好的靶向性和增强的生物活性，并为控制被包裹部分的释放曲线提供了多种手段。在不同的纳米颗粒中，无机纳米颗粒（银、金、铈、铁、硒、碲、锌等）由于其纳米形式下独特的生物活性而占有重要地位。硒作为一种必需的微量元素，在生物体的生长和发育中起着至关重要的作用。在医学上，它作为一种治疗因子在推荐剂量下没有明显的不良反应，因此引起了极大的关注。硒纳米颗粒可以通过物理、生物和化学方法制备。与其他方法相比，纳米颗粒的生物合成显示出优势，因为它环保、相对可重复、易于实现、可生物降解，并且通常能产生更稳定的材料。几项研究调查了尺寸、形状和合成方法对其在生物系统中应用的影响。本综述重点关注硒纳米颗粒的合成方法，特别是硒纳米颗粒的生物合成及其生物医学特性，如抗菌、抗病毒、抗真菌和抗寄生虫特性。最后，还对硒纳米颗粒的未来进行了全面展望。
