Haapala Eero A, Kuronen Emmi, Ihalainen Johanna K, Lintu Niina, Leppänen Marja H, Tompuri Tuomo, Atalay Mustafa, Schwab Ursula, Lakka Timo A
Sports & Exercise Medicine, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Scand J Med Sci Sports. 2023 Jun;33(6):1000-1009. doi: 10.1111/sms.14337. Epub 2023 Feb 19.
Systemic low-grade inflammation has been proposed as an underlying pathophysiological mechanism for cardiometabolic diseases. We investigated the associations of physical fitness with a systemic low-grade inflammatory state in a population sample of children.
Altogether 391 children aged 6-9 years were examined. Cardiorespiratory fitness (maximal power output, W ) was assessed by a maximal cycle ergometer test and neuromuscular fitness by hand grip strength, sit-up, standing long jump, 50-meter shuttle run, static balance, sit-and-reach, and box and block tests. Body fat percentage (BF%) and lean mass (LM) were assessed by dual-energy X-ray absorptiometry (DXA). High sensitivity C-reactive protein (hs-CRP), leptin, leptin receptor, high molecular weight adiponectin (HMW-adiponectin), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and glycoprotein acetyls (GlycA) were assessed from fasting blood samples. The modified inflammatory score (IS) was calculated using the population-specific z-scores and formula ( hs-CRP + leptin + IL-6 + TNF-α + GlycA)- leptin receptor- HMW-adiponectin. The data were analyzed using linear regression analyses.
Higher W /kg of body mass (β = -0.416, 95% CI = -0.514 to -0.318), higher number of completed sit-ups (β = -0.147, 95% CI = -0.244 to -0.049), a longer distance jumped in the standing long jump test (β = -0.270, 95% CI = -0.371 to -0.169), and a shorter time in the 50-meter shuttle run test (β = 0.123, 95% CI = 0.022 to 0.223) were associated with lower IS. None of these associations remained statistically significant after adjustment for BF%.
Higher physical fitness is associated with a more favorable inflammatory biomarker profile in children. However, the associations were explained by BF%.
全身性低度炎症被认为是心脏代谢疾病潜在的病理生理机制。我们在儿童人群样本中研究了体能与全身性低度炎症状态之间的关联。
共检查了391名6至9岁的儿童。通过最大运动负荷蹬车试验评估心肺适能（最大功率输出，瓦特），通过握力、仰卧起坐、立定跳远、50米往返跑、静态平衡、坐位体前屈以及箱框测试评估神经肌肉适能。采用双能X线吸收法（DXA）评估体脂百分比（BF%）和去脂体重（LM）。从空腹血样中检测高敏C反应蛋白（hs-CRP）、瘦素、瘦素受体、高分子量脂联素（HMW-脂联素）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和糖蛋白乙酰化产物（GlycA）。使用特定人群的z分数和公式（hs-CRP + 瘦素 + IL-6 + TNF-α + GlycA）-瘦素受体-HMW-脂联素计算改良炎症评分（IS）。采用线性回归分析对数据进行分析。
较高的每千克体重瓦特数（β = -0.416，95%可信区间 = -0.514至-0.318）、较多的仰卧起坐完成次数（β = -0.147，95%可信区间 = -0.244至-0.049）、立定跳远测试中较长的跳跃距离（β = -0.270，95%可信区间 = -0.371至-0.169）以及50米往返跑测试中较短的时间（β = 0.123，95%可信区间 = 0.022至0.223）与较低的IS相关。在调整BF%后，这些关联均不再具有统计学意义。
较高的体能与儿童更有利的炎症生物标志物谱相关。然而，这些关联可由BF%来解释。
