Clarke W L, Cox D, Gonder-Frederick L A, Carter W, Pohl S L
Department of Pediatrics, University of Virginia Medical School, Charlottesville 22908.
Diabetes Care. 1987 Sep-Oct;10(5):622-8. doi: 10.2337/diacare.10.5.622.
Although the scientific literature contains numerous reports of the statistical accuracy of systems for self-monitoring of blood glucose (SMBG), most of these studies determine accuracy in ways that may not be clinically useful. We have developed an error grid analysis (EGA), which describes the clinical accuracy of SMBG systems over the entire range of blood glucose values, taking into account 1) the absolute value of the system-generated glucose value, 2) the absolute value of the reference blood glucose value, 3) the relative difference between these two values, and 4) the clinical significance of this difference. The EGA of accuracy of five different reflectance meters (Eyetone, Dextrometer, Glucometer I, Glucometer II, Memory Glucometer II), a visually interpretable glucose reagent strip (Glucostix), and filter-paper spot glucose determinations is presented. In addition, reanalyses of a laboratory comparison of three reflectance meters (Accucheck II, Glucometer II, Glucoscan 9000) and of two previously published studies comparing the accuracy of five different reflectance meters with EGA is described. EGA provides the practitioner and the researcher with a clinically meaningful method for evaluating the accuracy of blood glucose values generated with various monitoring systems and for analyzing the clinical implications of previously published data.
尽管科学文献中有大量关于血糖自我监测（SMBG）系统统计准确性的报告，但这些研究大多以可能对临床无用的方式来确定准确性。我们开发了一种误差网格分析（EGA），它能在考虑以下因素的情况下，描述SMBG系统在整个血糖值范围内的临床准确性：1）系统生成的血糖值的绝对值；2）参考血糖值的绝对值；3）这两个值之间的相对差异；4）这种差异的临床意义。本文展示了五种不同反射式血糖仪（Eyetone、Dextrometer、血糖仪I、血糖仪II、记忆血糖仪II）、一种视觉上可解读的葡萄糖试纸（Glucostix）以及滤纸斑点葡萄糖测定法的准确性的误差网格分析结果。此外，还描述了对三种反射式血糖仪（Accucheck II、血糖仪II、Glucoscan 9000）的实验室比较以及两项先前发表的使用误差网格分析比较五种不同反射式血糖仪准确性的研究的重新分析。误差网格分析为从业者和研究人员提供了一种具有临床意义的方法，用于评估使用各种监测系统生成的血糖值的准确性，并分析先前发表数据的临床意义。
