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评价类间质性肺炎:10 年分析。

Evaluation of cases with hypersensitivity pneumonia: 10 year analysis.

机构信息

Department of Occupational Diseases, Ankara Atatürk Sanatoryum Education and Research Hospital, Health Science University, Ankara, Turkey.

出版信息

Clin Respir J. 2023 Apr;17(4):329-338. doi: 10.1111/crj.13598. Epub 2023 Feb 13.

Abstract

INTRODUCTION

The aim of this study was to examine the clinical features of hypersensitivity pneumonia (HP) cases, diagnostic methods, and related conditions in our hospital, which is a reference clinic in Turkey for chest disease.

METHODS

The population of this retrospective cross-sectional study consists of all hypersensitivity pneumonia patients followed in a tertiary hospital between 2010 and 2019. The data of 78 patients were included in the analysis. Data were grouped by source of exposure (occupational, environmental, and cryptogenic) by examining the files of the patients.

RESULTS

Occupational risk factors were detected in 29 (37.2%) of the cases, environmental risk factors were found in 24 (30.8%) cases, neither occupational nor environmental risk factors were detected in 25 (32%) cases, and they were evaluated as cryptogenic. The time from the onset of symptoms to diagnosis was 15.8 ± 26.6 months. The time from the onset of symptoms to diagnosis was found to be longer in the group with occupational risk factors compared with the other groups and was statistically significant (0.044).

CONCLUSION

HP is a immune-mediated interstitial lung disease induced by repeated exposure to environmental and occupational antigens. Etiological agent can be detected in HP patients by detailed questioning of occupational and environmental exposure that may be associated with the onset of symptoms in cases with suspected HP.

摘要

介绍

本研究旨在探讨我院(土耳其胸部疾病参考诊所)中过敏性肺炎(HP)病例的临床特征、诊断方法和相关情况。

方法

本回顾性横断面研究的人群包括 2010 年至 2019 年在一家三级医院接受治疗的所有过敏性肺炎患者。对 78 名患者的档案进行分析,将患者分为职业性、环境性和特发性(原因不明)暴露源组。

结果

29 例(37.2%)患者存在职业性危险因素,24 例(30.8%)患者存在环境性危险因素,25 例(32%)患者既无职业性也无环境性危险因素,被评估为特发性。从症状出现到诊断的时间为 15.8±26.6 个月。与其他组相比,职业性危险因素组的症状出现到诊断的时间更长,且具有统计学意义(0.044)。

结论

HP 是一种由反复暴露于环境和职业抗原引起的免疫介导的间质性肺疾病。通过详细询问可能与可疑 HP 病例发病有关的职业和环境暴露情况,可在 HP 患者中检测到病因。

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