Clinic of Occupational Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Türkiye.
Tuberk Toraks. 2023 Mar;71(1):94-104. doi: 10.5578/tt.20239911.
Hypersensitivity pneumonitis (HP) is an immunological lung disease that affects individuals who are sensitive and susceptible to occupational and environmental exposures. While clinical and radiological findings may resemble other interstitial lung diseases, identifying the causative agents can aid in the differential diagnosis. However, this can be challenging and may result in delayed diagnosis and poor prognosis. A gold standard test for diagnosis is currently unavailable, and therefore, a multidisciplinary approach involving a clinician, radiologist, and pathologist is necessary. Avoiding exposure is the first step in treatment, with immunosuppressive therapeutics also being used. Antifibrotic agents show promise for future treatment approaches. Despite recent advancements in data and guidelines, knowledge about managing occupational HP remains limited. This review provides a summary of the epidemiological, clinical, and radiological findings, as well as diagnostic and treatment principles of occupational HP based on current literature.
过敏性肺炎(HP)是一种免疫性肺部疾病,影响对职业和环境暴露敏感和易感的个体。虽然临床和影像学表现可能类似于其他间质性肺疾病,但识别病因有助于鉴别诊断。然而,这可能具有挑战性,并可能导致诊断延迟和预后不良。目前尚无诊断的金标准测试,因此需要临床医生、放射科医生和病理学家共同参与的多学科方法。避免暴露是治疗的第一步,也可以使用免疫抑制疗法。抗纤维化药物为未来的治疗方法带来了希望。尽管最近在数据和指南方面取得了进展,但对于职业性 HP 的管理知识仍然有限。本综述根据当前文献,总结了职业性 HP 的流行病学、临床和影像学表现,以及诊断和治疗原则。