Zhang Y, Ihlen H, Myhre E, Levorstad K, Nitter-Hauge S
Br Heart J. 1985 Oct;54(4):384-91. doi: 10.1136/hrt.54.4.384.
In an attempt to develop a new approach to the non-invasive measurement of mitral regurgitation, Doppler echocardiography and left ventriculography were performed in 20 patients without valvar heart disease (group A) and in 30 patients with pure mitral regurgitation (group B). Volumetric flows through the aortic and the mitral orifices were determined by Doppler echocardiography. Aortic flow (AF) was calculated as the product of the aortic orifice area and the systolic velocity integral. The mitral flow (MF) was calculated as the product of the corrected mitral orifice area and the diastolic velocity integral. The mitral regurgitant fraction (RF) was calculated as RF = 1 - AF/MF. In group A aortic and mitral flow were very similar and the difference between the two did not differ significantly from zero. In group B the mitral flow was significantly larger than the aortic flow. There was a good correlation (r = 0.82) between the regurgitant fraction determined by Doppler echocardiography and the regurgitant grades determined by left ventriculography. The regurgitant fraction increased significantly with each grade of severity. These results show that Doppler echocardiography can be used to give a reliable measure of both aortic and mitral flow. This technique is a new and promising approach to the non-invasive measurement of mitral regurgitation.
为尝试开发一种二尖瓣反流无创测量的新方法，对20例无瓣膜性心脏病患者（A组）和30例单纯二尖瓣反流患者（B组）进行了多普勒超声心动图和左心室造影检查。通过多普勒超声心动图测定通过主动脉口和二尖瓣口的容积流量。主动脉流量（AF）计算为主动脉口面积与收缩期速度积分的乘积。二尖瓣流量（MF）计算为校正后的二尖瓣口面积与舒张期速度积分的乘积。二尖瓣反流分数（RF）计算为RF = 1 - AF/MF。在A组中，主动脉流量和二尖瓣流量非常相似，两者之间的差异与零无显著差异。在B组中，二尖瓣流量明显大于主动脉流量。多普勒超声心动图测定的反流分数与左心室造影测定的反流分级之间存在良好的相关性（r = 0.82）。反流分数随严重程度的每一级显著增加。这些结果表明，多普勒超声心动图可用于可靠测量主动脉流量和二尖瓣流量。该技术是二尖瓣反流无创测量的一种新的且有前景的方法。
