Zhang Y, Nitter-Hauge S, Ihlen H, Rootwelt K, Myhre E
Br Heart J. 1986 Jan;55(1):32-8. doi: 10.1136/hrt.55.1.32.
In an attempt to develop a new approach to the non-invasive measurement of aortic regurgitation, transmitral volumetric flow (MF) and left ventricular total stroke volume (SV) were measured by Doppler and cross sectional echocardiography in 23 patients without aortic valve disease (group A) and in 26 patients with aortic regurgitation (group B). The transmitral volumetric flow was obtained by multiplying the corrected mitral orifice area by the diastolic velocity integral, and the left ventricular total stroke volume was derived by subtracting the left ventricular end systolic volume from the end diastolic volume. The aortic regurgitant fraction (RF) was calculated as: RF = 1 - MF/SV. In group A there was a close agreement between the transmitral volumetric flow and the left ventricular total stroke volume, and the difference between the two measurements did not differ significantly from zero. In group B the left ventricular total stroke volume was significantly larger than the transmitral volumetric flow, and there was good agreement between the regurgitant fractions determined by Doppler echocardiography and radionuclide ventriculography. Discrepancies between the two techniques were found in patients with combined aortic and mitral regurgitation or a low angiographic left ventricular ejection fraction (less than 35%). The effective cardiac output measured by Doppler echocardiography accorded well with that measured by the Fick method. Doppler echocardiography provides a new and promising approach to the non-invasive measurement of aortic regurgitation.
为了开发一种新的无创测量主动脉瓣反流的方法，对23例无主动脉瓣疾病的患者（A组）和26例有主动脉瓣反流的患者（B组），采用多普勒和横截面超声心动图测量经二尖瓣容积流量（MF）和左心室总搏出量（SV）。经二尖瓣容积流量通过将校正后的二尖瓣口面积乘以舒张期速度积分获得，左心室总搏出量通过从舒张末期容积中减去左心室收缩末期容积得出。主动脉瓣反流分数（RF）计算为：RF = 1 - MF/SV。在A组中，经二尖瓣容积流量与左心室总搏出量之间密切相关，两种测量值之间的差异与零无显著差异。在B组中，左心室总搏出量显著大于经二尖瓣容积流量，并且多普勒超声心动图和放射性核素心室造影测定的反流分数之间具有良好的一致性。在合并主动脉瓣和二尖瓣反流或血管造影左心室射血分数低（小于35%）的患者中发现了两种技术之间的差异。多普勒超声心动图测量的有效心输出量与菲克法测量的结果吻合良好。多普勒超声心动图为无创测量主动脉瓣反流提供了一种新的、有前景的方法。
