Calvo W, Fliedner T M, Herbst E W, Hügl E, Bödey B
Department of Clinical Physiology and Occupational Medicine, University of Ulm, Federal Republic of Germany.
Exp Hematol. 1987 Dec;15(11):1171-8.
Dogs exposed to a fatal radiation dose of 12 Gy were rescued by transfusion of autologous blood leukocytes. A severe acute and long-lasting damage to the thymus was observed. The acute damage, as observed on the tenth day, consisted of a marked reduction in the number of lymphocytes, degeneration of Hassall's bodies, and hemorrhage. Long-term effects, observed several months after irradiation, were partial to total atrophy of the thymus. Regeneration, when it occurred, was limited to a few small isolated areas in which lymphopoiesis was supported by epithelial reticular cells. In contrast, the lymph nodes of all dogs had abundant cortical lymphopoiesis. The abundant hemopoiesis present in the marrow from the tenth day after irradiation until the end of the observation period should have provided sufficient circulating precursor cells to seed the thymus and regenerate the organ to the same extent as that observed in the other blood-forming organs. The impairment of lymphopoietic regeneration in the thymus seems to be due, therefore, to damage caused by irradiation on the specific stroma of the organ, which is not able to support such activity.
暴露于12戈瑞致死性辐射剂量下的犬只通过自体血白细胞输注得以挽救。观察到胸腺受到严重的急性和持久性损伤。在第10天观察到的急性损伤包括淋巴细胞数量显著减少、哈氏小体变性和出血。照射数月后观察到的长期影响是胸腺部分至完全萎缩。再生情况（若发生）仅限于少数几个小的孤立区域，其中淋巴细胞生成由上皮网状细胞支持。相比之下，所有犬只的淋巴结都有丰富的皮质淋巴细胞生成。从照射后第10天直至观察期结束，骨髓中存在的丰富造血应该提供了足够的循环前体细胞来播种胸腺并使该器官再生至与其他造血器官观察到的相同程度。因此，胸腺中淋巴细胞生成再生的受损似乎是由于照射对该器官特定基质造成的损伤，这种基质无法支持此类活动。
