肼屈嗪诱导瑞士小鼠肺癌发生过程中超氧化物歧化酶肺活性及铜浓度的变化

Changes in lung activity of superoxide dismutase and copper concentration during lung tumorigenesis by hydralazine in Swiss mice.

作者信息

Drozdz M, Luciak M, Jendryczko A, Magner K

机构信息

Department of Biochemistry and Chemistry, Silesian Medical School, Katowice, Poland.

出版信息

Exp Pathol. 1987;32(2):119-22. doi: 10.1016/s0232-1513(87)80068-3.

DOI:10.1016/s0232-1513(87)80068-3

PMID:3678455

Abstract

Hydralazine (1-hydrazinophthalazine) was administered in drinking water as a 0.0312% solution to randomly bred Swiss mice for life beginning at 5 weeks of age. The treatments gave rise to statistically significant incidences of lung tumors: 55% in females and 43% in males. A decreased copper concentration and superoxide dismutase activity in the lung of mice were observed. The role of copper and superoxide dismutase in the malignant process is briefly discussed.

摘要

从5周龄开始，将肼屈嗪（1-肼基酞嗪）以0.0312%的溶液形式添加到饮用水中，喂给随机繁殖的瑞士小鼠直至其生命结束。这些处理导致了肺部肿瘤的发生率具有统计学意义：雌性为55%，雄性为43%。观察到小鼠肺部铜浓度降低和超氧化物歧化酶活性降低。简要讨论了铜和超氧化物歧化酶在恶性过程中的作用。