盐酸1-肼基酞嗪对小鼠的致瘤作用。

Tumorigenic effect of 1-hydrazinophthalazine hydrochloride in mice.

作者信息

Toth B

出版信息

J Natl Cancer Inst. 1978 Nov;61(5):1363-5. doi: 10.1093/jnci/61.5.1363.

DOI:10.1093/jnci/61.5.1363

Abstract

A solution of 0.125% 1-hydrazinophthalazine hydrochloride, an antihypertensive drug widely used in humans, was given continuously in drinking water for the life-spans of randomly bred Swiss mice. Consumption of the chemical significantly increased the lung tumor incidence from 36 to 60% in females and from 26 to 46% in males, compared to controls. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs.

摘要

一种0.125%盐酸1-肼基酞嗪溶液（一种广泛用于人类的降压药）在随机繁殖的瑞士小鼠的整个生命周期中持续添加到饮用水中。与对照组相比，该化学品的摄入使雌性小鼠的肺部肿瘤发生率从36%显著增加到60%，雄性小鼠从26%增加到46%。组织病理学上，这些肿瘤被分类为肺腺瘤和腺癌。