Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials (State Key Laboratory Cultivation Base), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P. R. China.
Shenzhen Grubbs Institute and Department of Chemistry, Guang-dong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, P. R. China.
Org Lett. 2023 Feb 24;25(7):1166-1171. doi: 10.1021/acs.orglett.3c00145. Epub 2023 Feb 14.
Deconstructive alkynylation of an unstrained ketone catalyzed by an organic photocatalyst under blue light irradiation is reported for the first time. A broad substrate scope with up to 63 examples, excellent functional group tolerance, and gram scale reaction demonstrated the practicality of this novel alkynylation method. The dihydroquinazolinone derivative of trifluoroacetophenone had been proved to have potential as a novel trifluoromethylation reagent after working well for the trifluoromethylation reaction with various alkynyl bromides.
首次报道了在蓝光照射下，有机光催化剂催化的未受应变的酮的解构炔基化反应。该方法具有广泛的底物范围（多达 63 个实例）、优异的官能团耐受性和克级规模的反应，证明了这种新型炔基化方法的实用性。三氟乙酰苯酮的二氢喹唑啉酮衍生物在与各种炔基溴化物的三氟甲基化反应中表现良好后，已被证明是一种新型的三氟甲基化试剂。
