Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China.
Department of Health Psychology, School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, People's Republic of China.
BMC Womens Health. 2023 Feb 14;23(1):67. doi: 10.1186/s12905-023-02222-5.
High sedentary behavior and poor health-related quality of life (HRQoL) were common among women with polycystic ovary syndrome (PCOS). However, the association of sedentary behavior with HRQoL among infertile women with PCOS is still unknown. This study aimed to investigate the association of sedentary behavior with HRQoL among them.
A cross-sectional study was conducted with 283 participants recruited from infertility outpatient clinic. A self-administered, structured questionnaire including the modified PCOS health-related QoL questionnaire (MPCOSQ), the International Physical Activity Questionnaire short form (IPAQ-SF), the Patient Health Questionnaire-9 (PHQ-9), and the Generalized Anxiety Disorder-7 (GAD-7) was used. Anthropometric and laboratory indictors related to PCOS were also collected. Multivariable linear regression analyses were performed to identify the associations. Bonferroni correction was utilized for multiple testing correction.
Sedentary behavior was associated with reduced HRQoL among this group. Specifically, over seven hours per day of sedentary behavior was strongly associated with total and several aspects of HRQoL (β ranged from - 0.378 to - 0.141, all P < 0.0063) after adjusting for physical activity, anxiety and depression. In addition, elevated BMI (β = - 0.407, P < 0.001) and anxiety (β ranged from - 0.410 to - 0.245, all P < 0.0063) were associated with poor HRQoL, while physical activity and depression were not.
Sedentary behavior is an important behavior among infertile women with PCOS as it was associated with poorer HRQoL. Future interventions seeking to improve HRQoL should be considered to reduce sedentary behavior and psychological burden as primary intervention targets.
多囊卵巢综合征（PCOS）女性普遍存在久坐行为和较差的健康相关生活质量（HRQoL）。然而，不孕 PCOS 女性的久坐行为与 HRQoL 的关系尚不清楚。本研究旨在调查其之间的关联。
采用横断面研究，从不孕门诊招募了 283 名参与者。使用自我管理的结构化问卷，包括改良的多囊卵巢综合征相关生活质量问卷（MPCOSQ）、国际体力活动问卷短表（IPAQ-SF）、患者健康问卷-9（PHQ-9）和广泛性焦虑障碍-7（GAD-7）。还收集了与 PCOS 相关的人体测量和实验室指标。采用多变量线性回归分析来确定关联。采用 Bonferroni 校正进行多重检验校正。
久坐行为与该人群的 HRQoL 降低有关。具体来说，每天久坐超过 7 小时与总 HRQoL 和几个方面的 HRQoL 呈强相关（β 范围从-0.378 到-0.141，所有 P<0.0063），调整了体力活动、焦虑和抑郁之后。此外，BMI 升高（β=-0.407，P<0.001）和焦虑（β 范围从-0.410 到-0.245，所有 P<0.0063）与较差的 HRQoL 相关，而体力活动和抑郁则没有。
久坐行为是不孕 PCOS 女性的重要行为，因为它与较差的 HRQoL 有关。未来寻求改善 HRQoL 的干预措施应考虑将减少久坐行为和心理负担作为主要干预目标。
