原发性上颌窦癌肉瘤的多学科治疗：4 年随访病例报告及文献复习。

Primary maxillary sinus carcinosarcoma with multidisciplinary management: a case report with 4 years follow-up and literature review.

机构信息

Department of Oral and Maxillofacial Surgery, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.

Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, NO.14, 3rd Section of Ren Min Nan Rd., Chengdu, 610041, Sichuan, China.

出版信息

BMC Oral Health. 2023 Feb 14;23(1):96. doi: 10.1186/s12903-022-02604-5.

DOI:10.1186/s12903-022-02604-5

PMID:36788533

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9926723/

Abstract

BACKGROUND

Primary maxillary sinus carcinosarcoma (CS) is an extremely rare malignant tumor characterized by biphasic histologic components, lack of standardized treatment, high recurrence rate, and poor prognosis. This paper presents a case of primary maxillary sinus CS and its treatment.

CASE PRESENTATION

A 39-year-old female patient complained of right facial pain and maxillary teeth numbness on March 21, 2018. Computed tomography examination revealed a malignant mass with osteolytic destruction. Preoperative biopsy suggested sarcomatoid carcinoma or CS. A total right maxillectomy under general anesthesia was performed on April 12, 2018. The final staging was T3N0M0 (ACJJ 2019). Postoperative radiotherapy and chemotherapy were performed. On May 26, 2018, the patient received the first cycle of doxorubicin plus ifosfamide. Two days before radiotherapy, the patient received an intra-oral prosthesis. From June 20, 2018, to August 22, 2018, the patient received concurrent chemoradiotherapy: radiotherapy (60 Gy in 30 fractions) and the second cycle of doxorubicin. Then, the patient received four cycles of doxorubicin plus ifosfamide. The patient was followed for 39 months with no evidence of disease.

CONCLUSION

Using multidisciplinary therapy, clinical-stage T3N0M0 (ACJJ 2019) maxillary sinus CS may achieve a good prognosis.

摘要

背景

原发性上颌窦癌肉瘤（CS）是一种极其罕见的恶性肿瘤，其特征为双相组织学成分、缺乏标准化治疗、高复发率和预后不良。本文报告了一例原发性上颌窦 CS 及其治疗。

病例介绍

一名 39 岁女性患者于 2018 年 3 月 21 日出现右侧面部疼痛和上颌牙齿麻木。计算机断层扫描检查显示恶性肿块伴溶骨性破坏。术前活检提示肉瘤样癌或 CS。2018 年 4 月 12 日，在全麻下进行了全右上颌骨切除术。最终分期为 T3N0M0（ACJJ 2019）。术后行放疗和化疗。2018 年 5 月 26 日，患者接受了第一周期多柔比星加异环磷酰胺。放疗前两天，患者接受了口腔义齿。从 2018 年 6 月 20 日至 8 月 22 日，患者接受了同期放化疗：放疗（60 Gy 分 30 次）和第二周期多柔比星。然后，患者接受了四个周期的多柔比星加异环磷酰胺。患者随访 39 个月，无疾病证据。