Department of Dermatology, Mohammed VI University Hospital of Oujda, Medical School of Oujda, Mohammed First University of Oujda, Oujda, Morocco.
Department of Epidemiology, Clinical Research and Public Health Laboratory, Medical School of Oujda, Mohammed First University of Oujda, Oujda, Morocco.
J Cutan Pathol. 2023 May;50(5):415-419. doi: 10.1111/cup.14409. Epub 2023 Mar 3.
Cutaneous adverse effects of imatinib are common and well documented in the literature. However, imatinib-induced lichen planus is an uncommon side effect with only four reported cases. In addition, reactivation of hepatitis B is an extremely rare association. We report two cases of imatinib-induced lichen planus, one of which is associated with hepatitis B reactivation, and one case of lichenoid eruption caused by imatinib. The aim of our report is to make physicians aware of this rare association between lichen planus and imatinib. We also recommend screening for hepatitis B virus before starting treatment with imatinib to avoid serious complications.
伊马替尼的皮肤不良反应在文献中有大量记载。然而，伊马替尼引起的扁平苔藓是一种罕见的副作用，仅有 4 例报告。此外，乙型肝炎再激活是一种极其罕见的关联。我们报告了两例伊马替尼诱导的扁平苔藓，其中一例与乙型肝炎再激活有关，另一例为伊马替尼引起的苔藓样疹。我们报告的目的是让医生意识到扁平苔藓和伊马替尼之间的这种罕见关联。我们还建议在开始伊马替尼治疗前筛查乙型肝炎病毒，以避免严重并发症。
