双克罗烷型A，一种具有C-16-C-12'键联的抗肝纤维化19-克罗烷二萜二聚体，源自……
Biscroyunoid A, an Anti-Hepatic Fibrotic 19--Clerodane Diterpenoid Dimer with a C-16-C-12' Linkage from .
作者信息
Li Wei, Gan Lu, Yuan Fang-Yu, Sang Jun, Huang Dong, Yin Ai-Ping, Pu Rong, Tang Gui-Hua, Guo Dean, Yin Sheng
机构信息
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, People's Republic of China.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
出版信息
J Nat Prod. 2023 Feb 24;86(2):434-439. doi: 10.1021/acs.jnatprod.2c01054. Epub 2023 Feb 15.
Biscroyunoid A (), a 19--clerodane diterpenoid dimer featuring a unique C-16-C-12' linkage and containing an unusual 4,7-dihydro-5-spiro[benzofuran-6,1'-cyclohexane] motif, together with its biosynthetic precursor, croyunoid A (), were isolated from . Their structures were determined by spectroscopic, computational, and single-crystal X-ray diffraction methods. Compound exerted an antihepatic fibrosis effect in LX-2 cells via inhibition of TGFβ-Smad2/3 signaling.
双克罗云诺伊德A（），一种具有独特C-16-C-12'键且含有不寻常的4,7-二氢-5-螺[苯并呋喃-6,1'-环己烷]基序的19- clerodane二萜二聚体，与其生物合成前体克罗云诺伊德A（）一起，从……中分离得到。它们的结构通过光谱、计算和单晶X射线衍射方法确定。化合物在LX-2细胞中通过抑制TGFβ-Smad2/3信号传导发挥抗肝纤维化作用。
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