丁基羟基茴香醚对大鼠肝脏S9制剂体外代谢N-亚硝基二正丁胺和N-亚硝基丁基（4-羟基丁基）胺的影响。
Effect of butylated hydroxyanisole on the metabolism of N-nitrosodi-n-butylamine and N-nitrosobutyl(4-hydroxybutyl)amine by rat hepatic S9 preparations in vitro.
作者信息
Pastorelli R, Ancidei A, Fanelli R, Airoldi L
机构信息
Laboratory of Environmental Pharmacology and Toxicology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
出版信息
IARC Sci Publ. 1987(84):183-4.
N-Nitrosodi-n-butylamine (NDBA), the NADPH generating system and various concentrations of butylated hydroxyanisole (BHA) added to rat hepatic S9 fractions resulted in a significant drop (30-50%) in N-nitrosobutyl(4-hydroxybutyl)amine (NBHBA) formation and a consequent rise in the amount of substrate recovered unchanged. When NBHBA and NAD+ were incubated with BHA and S9 fractions, the amount of N-nitrosobutyl(3-carboxypropyl)amine (NBCPA) was decreased by 20-40%, and the amount of unmetabolized NBHBA increased.
将N-亚硝基二正丁胺（NDBA）、NADPH生成系统以及各种浓度的丁基羟基茴香醚（BHA）添加到大鼠肝脏S9组分中，导致N-亚硝基丁基（4-羟基丁基）胺（NBHBA）的生成量显著下降（30%-50%），从而使未发生变化而回收的底物量增加。当NBHBA和NAD+与BHA及S9组分一起孵育时，N-亚硝基丁基（3-羧丙基）胺（NBCPA）的量减少了20%-40%，未代谢的NBHBA量增加。
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