Switlyk Marta D, Hopland Andreas, Sivanesan Shivanthe, Brennhovd Bjørn, Ottosson Fredrik, Berner Kjetil, Axcrona Ulrika, Hole Knut H
Department of Radiology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Department of Urology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Eur J Radiol Open. 2023 Jan 28;10:100478. doi: 10.1016/j.ejro.2023.100478. eCollection 2023.
We aimed to evaluate the diagnostic potential of non-erectile multi-parametric magnetic resonance imaging (mpMRI) for preoperative assessment of primary penile squamous cell carcinoma (SCC).
Twenty-five patients who underwent surgery for penile SCC were included. Preoperative mpMRI without artificial erection was performed in all patients. The preoperative MRI protocol consisted of high-resolution morphological and functional sequences (diffusion-weighted imaging and dynamic contrast-enhanced MRI perfusion) covering the penis and lower pelvis. T and N staging, according to the 8th edition of the Union for International Cancer Control TNM classification, as well as the largest diameter and thickness/infiltration depth of the primary lesions were determined in all patients. Imaging data were retrospectively collected and compared with the final histopathology reports.
Very good agreement was observed between MRI and histopathology for the involvement of corpus spongiosum ( = 0.002) and good agreement was observed for the involvement of penile urethra and tunica albuginea/corpus cavernosum ( < 0.001 and = 0.007, respectively). Good agreement was observed between MRI and histopathology for overall T staging and weaker, but still good agreement was observed for N staging ( < 0.001 and = 0.002, respectively). A strong and significant correlation was observed between MRI and histopathology for the largest diameter and thickness/infiltration depth of the primary lesions ( < 0.001).
Good concordance was observed between MRI and histopathological findings. Our initial findings indicate that non-erectile mpMRI is useful in preoperative assessment of primary penile SCC.
我们旨在评估非勃起状态下多参数磁共振成像（mpMRI）对原发性阴茎鳞状细胞癌（SCC）术前评估的诊断潜力。
纳入25例行阴茎SCC手术的患者。所有患者均在非人工勃起状态下进行术前mpMRI检查。术前MRI检查方案包括覆盖阴茎和下腹部的高分辨率形态学和功能序列（扩散加权成像和动态对比增强MRI灌注）。根据国际癌症控制联盟第8版TNM分类确定所有患者的T和N分期，以及原发灶的最大直径和厚度/浸润深度。回顾性收集影像数据并与最终组织病理学报告进行比较。
MRI与组织病理学在海绵体受累方面一致性非常好（P = 0.002），在阴茎尿道和白膜/海绵体受累方面一致性良好（分别为P < 0.001和P = 0.007）。MRI与组织病理学在总体T分期方面一致性良好，在N分期方面一致性较弱，但仍为良好（分别为P < 0.001和P = 0.002）。MRI与组织病理学在原发灶的最大直径和厚度/浸润深度方面存在强烈且显著的相关性（P < 0.001）。
MRI与组织病理学结果一致性良好。我们的初步研究结果表明，非勃起状态下的mpMRI对原发性阴茎SCC的术前评估有用。
