Rokkam Meher Prasanna, Gora Olos, Konda Manikyeswara Rao, Koushik Ajay
Department of Orthopedics, Meher Hospital, Vijayawada, India.
Department of Physiotherapy, Vijaya Institute Medical Sciences College of Physiotherapy, NTR University of Health Sciences, Vijayawada, India.
Food Nutr Res. 2023 Jan 27;67. doi: 10.29219/fnr.v67.8972. eCollection 2023.
The demand for safe and efficacious botanical formulations to increase muscle mass, strength, and stamina is increasing among athletes and the general population. The nutraceutical supplements of medicinal plant origin exert minimal health concern.
This randomized, double-blind, placebo-controlled study was aimed to evaluate the ergogenic potential of a proprietary, standardized formulation (LI12542F6) of flower head and stem bark extracts.
Forty male participants 18-40 years of age were assigned to receive either a placebo ( = 20) or 650 mg/day LI12542F6 ( = 20) for 56 days. All participants performed a fixed set of resistance exercises during the intervention. The primary endpoint was the change from baseline muscle strength, assessed by one-repetition maximum (1-RM) bench and leg presses, and handgrip strength. The secondary endpoints included cable pull-down repetitions, time to exhaustion on a treadmill, mid-upper arm circumference (MUAC), body composition using dual-energy x-ray absorptiometry (DEXA), and free testosterone and cortisol levels in serum.
Fifty-six days supplementation of LI12542F6 significantly improved baseline bench press ( < 0.0001), leg press ( < 0.0001), handgrip strength ( < 0.0006), number of repetitions ( < 0.0001), and time to exhaustion ( < 0.0008), compared to placebo. Post-trial, the LI12542F6 group also showed significantly increased MUAC and improved body composition and serum hormone levels. The participants' hematology, clinical chemistry, and vital signs were within the normal range. No adverse events were observed.
This study demonstrates that LI12542F6 supplementation significantly increases muscle strength and size and improves endurance in healthy men. Also, LI12542F6 is well-tolerated by the participants.
运动员和普通人群对安全有效的植物配方产品以增加肌肉量、力量和耐力的需求不断增加。药用植物来源的营养补充剂对健康的影响微乎其微。
本随机、双盲、安慰剂对照研究旨在评估一种专有的、标准化的花头和茎皮提取物配方（LI12542F6）的促力能潜力。
40名年龄在18至40岁之间的男性参与者被分配接受安慰剂（n = 20）或每天650毫克LI12542F6（n = 20），为期56天。所有参与者在干预期间进行一组固定的抗阻运动。主要终点是通过一次重复最大值（1-RM）卧推和腿举以及握力评估的基线肌肉力量变化。次要终点包括下拉缆绳重复次数、跑步机上的疲劳时间、上臂中部周长（MUAC）、使用双能X射线吸收法（DEXA）测量的身体成分，以及血清中的游离睾酮和皮质醇水平。
与安慰剂相比，补充LI12542F6 56天显著改善了基线卧推（P < 0.0001）、腿举（P < 0.0001）、握力（P < 0.0006）、重复次数（P < 0.0001）和疲劳时间（P < 0.0008）。试验后，LI12542F6组的MUAC也显著增加，身体成分和血清激素水平得到改善。参与者的血液学、临床化学和生命体征均在正常范围内。未观察到不良事件。
本研究表明，补充LI12542F6可显著增加健康男性的肌肉力量和尺寸，并提高耐力。此外，参与者对LI12542F6耐受性良好。
