Salter Dawna, Swamy Shubhatara, Salis Kevin Manohar, Deep Dheeraj Kumar, Nadig Pratibha
Department of Clinical Research and Innovation, PLT Health Solutions, Inc., Morristown, NJ, United States.
Department of Pharmacology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, India.
Front Nutr. 2024 May 3;11:1393917. doi: 10.3389/fnut.2024.1393917. eCollection 2024.
Resistance exercise training (RET) is used to improve muscular strength and function. This study tested the hypothesis that RET alongside daily supplementation of a and extract blend (SMI) would augment bench press (BP) and leg extension (LE) strength and repetitions to failure (RTF) compared to RET alone. Ninety-nine men (age 22 ± 3) completed the trial after randomization into one of four groups: (A1) 425 mg SMI plus one RET set; (A2) 850 mg SMI plus one RET set; (P1) placebo plus one RET set; and (P2) placebo plus two RET sets. RET sets were 6-8 BP and LE repetitions at 80% of a progressive one repetition maximum (1-RM), performed 3x/week for 8 weeks. Strength and RTF were evaluated at baseline and days 14, 28, and 56 while serum values of total testosterone (TT), free testosterone (FT), and cortisol (C) values were evaluated at baseline and day 56. RET significantly ( < 0.05) increased 1-RM, RTF, and T measures above baselines regardless of group assignment, but the increases were greater in the supplemented groups. At week 8, A1 bench pressed more than P1 (71.5.5 ± 17.5 kg vs. 62.0 ± 15.3 kg, = 0.003), while A2 pressed 13.8 ± 3.0 kg more (95% CI 5.7-21.8, < 0.001) than P1 and 9.9 ± 13.0 kg more (95% CI 1.7-18.2, = 0.01) than P2. Also at week 8, the mean LE 1-RM of A1 (159.4 ± 22.6 kg) and A2 (162.2 ± 22.9 kg) was greater ( < 0.05) than that of P1 (142.2 ± 25.6 kg) and P2 (146.5 ± 19.7 kg). Supplementation improved RTF, TT, and FT values over those measured in exercise alone ( < 0.05), while C levels in A2 (9.3 ± 3.8 μg/dL) were lower than P2 (11.7 ± 3.8 μg/dL, < 0.05). Daily supplementation with SMI was well tolerated and may help optimize muscle adaptive responses to RET in men.
抗阻运动训练（RET）用于提高肌肉力量和功能。本研究检验了以下假设：与单独进行RET相比，RET联合每日补充α-硫辛酸和镁提取物混合物（SMI）能增强卧推（BP）和腿伸展（LE）力量以及至疲劳重复次数（RTF）。99名男性（年龄22±3岁）被随机分为四组之一后完成了试验：（A1）425毫克SMI加一组RET；（A2）850毫克SMI加一组RET；（P1）安慰剂加一组RET；（P2）安慰剂加两组RET。RET组为以渐进式一次重复最大值（1-RM）的80%进行6-8次BP和LE重复，每周进行3次，共8周。在基线以及第14、28和56天评估力量和RTF，而在基线和第56天评估血清总睾酮（TT）、游离睾酮（FT）和皮质醇（C）值。无论分组如何，RET均显著（P<0.05）提高了高于基线的1-RM、RTF和T指标，但补充组的增加幅度更大。在第8周时，A1组的卧推重量超过P1组（71.5±17.5千克对62.0±15.3千克，P=0.003），而A2组比P1组多推13.8±3.0千克（95%可信区间5.7-21.8，P<0.001），比P2组多推9.9±13.0千克（95%可信区间1.7-18.2，P=0.01）。同样在第8周时，A1组（159.4±22.6千克）和A2组（162.2±22.9千克）的平均LE 1-RM大于P1组（142.2±25.6千克）和P2组（146.5±19.7千克）（P<0.05）。与仅运动时测得的值相比，补充剂改善了RTF、TT和FT值（P<0.05），而A2组的C水平（9.3±3.8微克/分升）低于P2组（11.7±3.8微克/分升，P<0.05）。每日补充SMI耐受性良好，可能有助于优化男性肌肉对RET的适应性反应。
