Yu M C, Henderson B E
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles.
IARC Sci Publ. 1987(84):547-9.
Ho (1971) of Hong Kong first proposed consumption of Cantonese-style salted fish, a traditional food among southern Chinese, as a possible risk factor for nasopharyngeal carcinoma (NPC) in this high-risk population. Four case-control studies have examined Ho's hypothesis; all results are supportive. The most convincing evidence of a causal association between intake of salted fish and NPC derives from a recent case-control study of young Hong Kong Chinese. It is estimated that over 90% of NPC cases under age 35 in Hong Kong are due to intake of this food during childhood. Preliminary experimental data on Cantonese-style salted fish indicate that N-nitroso compounds may be involved in the carcinogenicity of this human food.
香港的何（1971年）首次提出，在中国南方人群这一高危人群中，食用具有广东风味的咸鱼（中国南方的传统食物）可能是鼻咽癌（NPC）的一个风险因素。四项病例对照研究检验了何的假说；所有结果均提供了支持。咸鱼摄入与鼻咽癌之间存在因果关联的最有说服力的证据来自最近一项针对年轻香港华人的病例对照研究。据估计，香港35岁以下的鼻咽癌病例中，超过90%是由于童年时期食用了这种食物所致。关于广东风味咸鱼的初步实验数据表明，N-亚硝基化合物可能与这种人类食物的致癌性有关。
