Mavrakis Manos, Juanes M Angeles
Institut Fresnel, CNRS, Aix-Marseille Univ, Centrale Marseille, 13013 Marseille, France.
School of Health and Life Science, Teesside University, Middlesbrough, TS1 3BX, United Kingdom; National Horizons Centre, Teesside University, Darlington DL1 1HG, United Kingdom; Centro de Investigación Príncipe Felipe, Valencia, 46012, Spain.
Curr Opin Cell Biol. 2023 Feb;80:102152. doi: 10.1016/j.ceb.2023.102152. Epub 2023 Feb 14.
How cells move is a fundamental biological question. The directionality of adherent migrating cells depends on the assembly and disassembly (turnover) of focal adhesions (FAs). FAs are micron-sized actin-based structures that link cells to the extracellular matrix. Traditionally, microtubules have been considered key to triggering FA turnover. Through the years, advancements in biochemistry, biophysics, and bioimaging tools have been invaluable for many research groups to unravel a variety of mechanisms and molecular players that contribute to FA turnover, beyond microtubules. Here, we discuss recent discoveries of key molecular players that affect the dynamics and organization of the actin cytoskeleton to enable timely FA turnover and consequently proper directed cell migration.
细胞如何移动是一个基本的生物学问题。贴壁迁移细胞的方向性取决于粘着斑（FAs）的组装和拆卸（周转）。粘着斑是微米大小的基于肌动蛋白的结构，将细胞与细胞外基质连接起来。传统上，微管被认为是触发粘着斑周转的关键。多年来，生物化学、生物物理学和生物成像工具的进步对许多研究小组揭示导致粘着斑周转的各种机制和分子参与者（除微管外）非常有价值。在这里，我们讨论了影响肌动蛋白细胞骨架动力学和组织的关键分子参与者的最新发现，以实现及时的粘着斑周转并因此实现适当的定向细胞迁移。
