控制人体微生物组。
Controlling the human microbiome.
机构信息
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Center for Artificial Intelligence and Modeling, The Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA.
出版信息
Cell Syst. 2023 Feb 15;14(2):135-159. doi: 10.1016/j.cels.2022.12.010.
We coexist with a vast number of microbes that live in and on our bodies. Those microbes and their genes are collectively known as the human microbiome, which plays important roles in human physiology and diseases. We have acquired extensive knowledge of the organismal compositions and metabolic functions of the human microbiome. However, the ultimate proof of our understanding of the human microbiome is reflected in our ability to manipulate it for health benefits. To facilitate the rational design of microbiome-based therapies, there are many fundamental questions to be addressed at the systems level. Indeed, we need a deep understanding of the ecological dynamics associated with such a complex ecosystem before we rationally design control strategies. In light of this, this review discusses progress from various fields, e.g., community ecology, network science, and control theory, that are helping us make progress toward the ultimate goal of controlling the human microbiome.
我们与大量生活在我们体内和体表的微生物共存。这些微生物及其基因统称为人类微生物组，它们在人类生理学和疾病中发挥着重要作用。我们已经获得了关于人类微生物组的生物体组成和代谢功能的广泛知识。然而，我们对人类微生物组的理解的最终证明体现在我们能够为了健康益处而对其进行操纵的能力上。为了促进基于微生物组的疗法的合理设计，在系统层面上有许多基本问题需要解决。事实上，在我们合理地设计控制策略之前，我们需要深入了解与这样一个复杂生态系统相关的生态动力学。有鉴于此，本综述讨论了来自不同领域的进展，例如群落生态学、网络科学和控制理论，这些进展正在帮助我们朝着控制人类微生物组的最终目标迈进。
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