Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China.
Clin Pediatr (Phila). 2023 Oct;62(10):1245-1253. doi: 10.1177/00099228231154949. Epub 2023 Feb 16.
Exchange blood transfusion (ET) reportedly improves the outcomes of the patients with severe pertussis accompanied with deadly complications continued to worsen despite intensive therapeutic measures. This study assessed the medical records of 12 patients with severe pertussis requiring ET therapy who were admitted to our medical center. Of the 12 patients requiring ET therapy, 8 survived and 4 died. The independent risk factors for requiring ET therapy in infants with severe pertussis were T ≥ 38.5°C (odds ratio [OR], 11.697; 95% confidence interval [CI], 1.325-262.184; = .046), C-reactive protein (CRP) >30 mg/L (OR, 62.393; 95% CI, 6.264-2381.773; = .004), and WBC > 40.0 × 10/L (OR, 68.509; 95% CI, 8.118-1829.695; = .001). ET therapy worked effectively for our severe pertussis cases. When the severe pertussis patients with T ≥ 38.5°C, CRP >30 mg/L, and WBC > 40.0 × 10/L, ET therapy might be taken into consideration.
据报道，交换输血（ET）可改善伴有致命并发症的重症百日咳患者的预后，尽管采取了强化治疗措施，但病情仍持续恶化。本研究评估了 12 例因严重百日咳需要 ET 治疗而入住我院的患者的病历。在需要 ET 治疗的 12 例患者中，8 例存活，4 例死亡。婴儿严重百日咳需要 ET 治疗的独立危险因素为 T≥38.5°C（比值比[OR]，11.697；95%置信区间[CI]，1.325-262.184；P=0.046）、C 反应蛋白（CRP）>30mg/L（OR，62.393；95% CI，6.264-2381.773；P=0.004）和白细胞计数（WBC）>40.0×10/L（OR，68.509；95% CI，8.118-1829.695；P=0.001）。ET 治疗对我们的严重百日咳病例有效。当严重百日咳患者 T≥38.5°C、CRP>30mg/L 和 WBC>40.0×10/L 时，可考虑进行 ET 治疗。
