Li Jianpeng, Zhao Manman, Huang Weidao, Huang Xuanxuan, Ou Yongqiang
Wuzhou Third People's Hospital, Wuzhou, Guangxi, China.
Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Microbiol Spectr. 2025 May 6;13(5):e0247424. doi: 10.1128/spectrum.02474-24. Epub 2025 Apr 10.
Tuberculosis (TB) is a serious respiratory disease posing significant public health threats, such as the variation in () lineages and their associated drug resistance across regions. In 2022, clinical data and culture-positive TB samples were collected from the Third People's Hospital in Wuzhou, China. drug resistance and lineage were analyzed using whole-genome sequencing, while logistic regression was applied to identify factors influencing patient outcomes. Among 169 strains analyzed, an overall drug resistance rate of 23.1% was observed. Multidrug-resistant or rifampicin-resistant cases constituted 7.7% of the strains. Most strains belonged to lineage 2 (69.8%), followed by lineage 4 (27.8%). Poor treatment adherence, being aged 65 or older, and retreatment emerged as risk factors for unfavorable outcomes. This pioneering survey provides crucial insights into TB patient characteristics, drug resistance patterns, and lineage distribution in Wuzhou, laying a foundation for future targeted TB control strategies in the region.IMPORTANCEIn 2022, tuberculosis (TB) was the second leading cause of death from a single infectious agent worldwide, posing a serious threat to global health. The epidemiological characteristics of TB vary considerably from country to country, and even from region to region within a single country, due to differences in the economy, medical conditions, education, and other factors. Understanding the current status of TB epidemics in the region is important, with practical implications for local diagnosis, treatment, and control. This genomic epidemiological survey has provided a first insight into the characteristics of TB patients, drug resistance rates, prevalence lineage, and factors associated with unfavorable outcomes in Wuzhou, China.
结核病（TB）是一种严重的呼吸道疾病，对公众健康构成重大威胁，例如不同地区结核分枝杆菌谱系的差异及其相关耐药性。2022年，从中国梧州第三人民医院收集了临床数据和培养阳性的结核病样本。使用全基因组测序分析耐药性和谱系，同时应用逻辑回归来确定影响患者预后的因素。在分析的169株菌株中，观察到总体耐药率为23.1%。耐多药或耐利福平病例占菌株的7.7%。大多数菌株属于谱系2（69.8%），其次是谱系4（27.8%）。治疗依从性差、年龄在65岁及以上以及再次治疗是不良预后的危险因素。这项开创性的调查为梧州结核病患者特征、耐药模式和谱系分布提供了关键见解，为该地区未来有针对性的结核病控制策略奠定了基础。重要性2022年，结核病是全球单一传染病导致死亡的第二大原因，对全球健康构成严重威胁。由于经济、医疗条件、教育等因素的差异，结核病的流行病学特征在不同国家之间，甚至在一个国家内的不同地区之间都有很大差异。了解该地区结核病流行的现状很重要，对当地的诊断、治疗和控制具有实际意义。这项基因组流行病学调查首次深入了解了中国梧州结核病患者的特征、耐药率、流行谱系以及与不良预后相关的因素。
