Yusharyahya Shannaz Nadia, Japranata Valdi Ven, Sitohang Irma Bernadette S, Legiawati Lili, Novianto Endi, Suseno Lis Surachmiati, Rachmani Karin
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia.
Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia.
Clin Cosmet Investig Dermatol. 2023 Feb 10;16:387-395. doi: 10.2147/CCID.S401839. eCollection 2023.
The efficacy of adipose-derived mesenchymal stem cells (ADMSCs) secretome for skin aging has been established, yet no studies hitherto directly investigated the best administration method for such purpose.
We aimed to compare microneedling (MN) versus fractional CO laser (FL) as methods of delivery for ADMSCs secretome in the treatment of aging skin.
A single-blind, randomized split-face clinical trial was conducted on 30 Indonesian women (aged 35-59 years old) with signs of facial cutaneous senescence. Their initial aging status was assessed by dermoscopy photoaging scale (DPAS) and Janus-III measurement system. In the second and fourth weeks, all participants were treated with both MN and FL, followed by the application of a four-fold concentrated ADMSC secretome. The assignment of which side of the face received MN or FL was done by computer-based randomization. Skin parameters were reevaluated on the fourth and sixth weeks, along with patient satisfaction, level of comfort, preference for administration techniques, and also adverse events experienced during the study. Appropriate statistical analyses were subsequently performed at a significance level of 0.05.
Significant improvements in total DPAS and wrinkles were found in the MN and FL groups at the end of the trial. In contrast, no statistical differences in all parameters were observed between groups in the fourth and sixth weeks. FL scored higher than MN for satisfaction and preference, but lower in terms of comfort. Pain, burning sensation, and itch were the side effects experienced by subjects upon treatment. Two patients had prolonged reddish skin succeeding FL treatment, which relieved with moisturizer application.
Both MN and FL yielded comparable results for improving several skin aging features. However, subjective preference for ADMSCs secretome administration method may differ when considering satisfaction, comfort, and possible adverse events.
脂肪间充质干细胞（ADMSCs）分泌组对皮肤衰老的功效已得到证实，但迄今为止尚无研究直接探究其最佳给药方法。
我们旨在比较微针（MN）与分次二氧化碳激光（FL）作为ADMSCs分泌组治疗皮肤老化的给药方法。
对30名有面部皮肤衰老迹象的印度尼西亚女性（年龄35 - 59岁）进行单盲、随机半脸临床试验。通过皮肤镜光老化量表（DPAS）和Janus - III测量系统评估她们的初始衰老状况。在第二周和第四周，所有参与者均接受MN和FL治疗，随后涂抹四倍浓缩的ADMSCs分泌组。通过计算机随机化确定面部哪一侧接受MN或FL治疗。在第四周和第六周重新评估皮肤参数，同时评估患者满意度、舒适度、对给药技术的偏好以及研究期间经历的不良事件。随后在显著性水平为0.05的情况下进行适当的统计分析。
试验结束时，MN组和FL组的总DPAS和皱纹均有显著改善。相比之下，在第四周和第六周，两组之间所有参数均未观察到统计学差异。FL在满意度和偏好方面得分高于MN，但在舒适度方面得分较低。疼痛、烧灼感和瘙痒是受试者治疗后经历的副作用。两名患者在接受FL治疗后皮肤发红持续时间延长，涂抹保湿霜后缓解。
MN和FL在改善多种皮肤衰老特征方面产生了相当的结果。然而，在考虑满意度、舒适度和可能的不良事件时，对ADMSCs分泌组给药方法的主观偏好可能存在差异。
