Damayanti Restu Harisma, Rusdiana Taofik, Wathoni Nasrul
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45353, Indonesia.
Clin Cosmet Investig Dermatol. 2021 Oct 5;14:1401-1412. doi: 10.2147/CCID.S331044. eCollection 2021.
Secretome, also known as conditioned medium, is a secreted molecule from mesenchymal stem cells (MSCs) that has a variety of biological activities that can be used in various therapies, especially on the skin applications. A lack of conventional therapies makes secretome as a promising alternative therapy. The presence of growth factors, cytokines, and extracellular vesicles including microvesicles and exosomes in secretome has been widely reported, which serves in improving the proliferation and migration of cells to help in skin regeneration. Therefore, we were able to optimize the use of this secretome in a well-needed special review related to its work in addressing various skin problems. So, in this article, we discussed the benefits and biological activity of secretome on the skin application. This review was compiled based on the approval of several sites, such as Scopus, PubMed, Science Direct, and Google Scholar with the terms "MSC secretome for skin," "secretome for skin," "secretome dermatology," "secretome conditioned medium for skin," "secretome conditioned medium for skin wound," "secretome conditioned medium for aging," "secretome conditioned medium for hair growth," and "secretome conditioned medium for psoriasis." A total of 215 articles were collected for selection, of which 90 articles were used. Based on the results, it was concluded that secretome has a variety of useful activities to regenerate and repair tissue damage that have not been used on the skin, such as for wound healing, photoprotection, promotion of hair growth, psoriasis treatment, and other application as antimicrobial.
分泌组，也被称为条件培养基，是间充质干细胞（MSC）分泌的一种分子，具有多种生物活性，可用于各种治疗，尤其是在皮肤应用方面。传统疗法的缺乏使得分泌组成为一种有前景的替代疗法。分泌组中存在生长因子、细胞因子以及包括微泡和外泌体在内的细胞外囊泡，这一点已被广泛报道，它们有助于改善细胞的增殖和迁移，从而促进皮肤再生。因此，我们能够在一篇急需的专题综述中优化对这种分泌组的使用，该综述涉及它在解决各种皮肤问题方面的作用。所以，在本文中，我们讨论了分泌组在皮肤应用方面的益处和生物活性。这篇综述是基于对多个数据库的检索编写而成，如Scopus、PubMed、ScienceDirect和谷歌学术，检索词包括“用于皮肤的MSC分泌组”“用于皮肤的分泌组”“分泌组皮肤病学”“用于皮肤的分泌组条件培养基”“用于皮肤伤口的分泌组条件培养基”“用于衰老的分泌组条件培养基”“用于头发生长的分泌组条件培养基”以及“用于银屑病的分泌组条件培养基”。总共收集了215篇文章以供筛选，其中90篇文章被采用。基于这些结果得出结论，分泌组具有多种有益活性，可用于再生和修复尚未应用于皮肤的组织损伤，如伤口愈合、光保护、促进头发生长、治疗银屑病以及其他作为抗菌剂的应用。
