Riahi Roya, Ghasemi Marziye, Shatouri Zahra Montazeri, Gharipour Mojgan, Maghami Mahboobeh, Melali Hamid, Sami Ramin, Tabatabaei Aminreza, Hosseini Sayed Mohsen
Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Medical Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2022 Dec 26;11:121. doi: 10.4103/abr.abr_86_21. eCollection 2022.
The aim of the study is to explore the risk factors of mortality for hospitalized patients in three designated hospitals in Isfahan province.
This retrospective cohort study was conducted on all positive coronavirus disease (COVID)-19 patients admitted to Khorshid, Isabn Maryam, and Amin hospitals in Isfahan province. The demographic, clinical, laboratory, and outcome data of patients who were died or discharged from February 24, 2020, to April 18, 2020, were extracted from patient's medical records.
Overall 1044 COVID-19 patients were included in this analysis. Based on the findings of this study, older age (≥65 years) (adjusted hazard ratio [aHR]: 2.06; 95% confidence interval [CI]: 1.13-3.76), chronic obstructive pulmonary disease (COPD) history (aHR: 2.52; 95% CI: 1.09-5.83), white blood cell (WBC) counts more than 10 × 10^3/L (aHR: 3.05; 95% CI: 1.42-6.55), Hb level <13 gr/L (aHR: 2.82; 95% CI: 1.34-5.93), bilateral pulmonary infiltrates (aHR: 2.02; 95% CI: 1.12-3.64) at admission, development of acute respiratory distress syndrome (ARDS) (aHR: 1.87; 95% CI: 1.01-3.47), and intensive care unit (ICU) admission (aHR: 2.09; 95% CI: 1.04-4.18) during hospitalization were risk factors for in-hospital mortality in patients with COVID-19.
Multiple factors were found related to the severity and death among COVID-19 patients. We were found that older age (≥65 years) with COPD history, high level of WBC, low level of Hb (<13 g/L), bilateral pulmonary infiltrates at admission, development of ARDS, and ICU admission during hospitalization were identified as risk factors of death among COVID-19 patients. More related studies are needed in the future.
本研究旨在探讨伊斯法罕省三家指定医院住院患者的死亡风险因素。
本回顾性队列研究针对伊斯法罕省霍尔希德医院、伊萨布恩·玛丽安医院和阿明医院收治的所有新型冠状病毒肺炎（COVID-19）阳性患者开展。从患者病历中提取2020年2月24日至2020年4月18日期间死亡或出院患者的人口统计学、临床、实验室及转归数据。
本分析共纳入1044例COVID-19患者。基于本研究结果，年龄较大（≥65岁）（调整后风险比[aHR]：2.06；95%置信区间[CI]：1.13 - 3.76）、有慢性阻塞性肺疾病（COPD）病史（aHR：2.52；95% CI：1.09 - 5.83）、白细胞（WBC）计数超过10×10³/L（aHR：3.05；95% CI：1.42 - 6.55）、血红蛋白（Hb）水平<13 g/L（aHR：2.82；95% CI：1.34 - 5.93）、入院时双侧肺部浸润（aHR：2.02；95% CI：1.12 - 3.64）、发生急性呼吸窘迫综合征（ARDS）（aHR：1.87；95% CI：1.01 - 3.47）以及住院期间入住重症监护病房（ICU）（aHR：2.09；95% CI：1.04 - 4.18）是COVID-19患者院内死亡的风险因素。
发现多种因素与COVID-19患者的病情严重程度及死亡相关。我们发现，年龄较大（≥65岁）且有COPD病史、白细胞水平高、血红蛋白水平低（<13 g/L）、入院时双侧肺部浸润、发生ARDS以及住院期间入住ICU被确定为COVID-19患者死亡的风险因素。未来需要更多相关研究。
