用于快速检测和生物成像甲醛的比率型荧光探针。
A ratiometric fluorescent probe for fast detection and bioimaging of formaldehyde.
机构信息
School of Life Science and Engineering, School of Chemistry, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
出版信息
Org Biomol Chem. 2023 Mar 8;21(10):2167-2171. doi: 10.1039/d2ob02314h.
A novel ratiometric probe (SWJT-10) based on isophorone derivatives has been designed and synthesized for the detection of formaldehyde (FA). This probe displayed an obvious ratiometric fluorescence response to FA with a blue shift from the NIR (680 nm) to the yellow light region (600 nm) in aqueous solution. And it showed good selectivity, high sensitivity and a fast response to FA (less than 5 s) due to a new recognition mechanism. Moreover, SWJT-10 has been applied to monitor FA in living cells and zebrafish.
一种基于异佛尔酮衍生物的新型比率探针（SWJT-10）已被设计并合成用于检测甲醛（FA）。该探针在水溶液中对 FA 表现出明显的比率荧光响应，从近红外（680nm）到黄光区（600nm）发生蓝移。并且由于新的识别机制，它对 FA 表现出良好的选择性、高灵敏度和快速响应（小于 5 秒）。此外，SWJT-10 已被应用于活细胞和斑马鱼中 FA 的监测。
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