School of Life Science and Engineering, School of Chemistry, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
Org Biomol Chem. 2023 Mar 8;21(10):2167-2171. doi: 10.1039/d2ob02314h.
A novel ratiometric probe (SWJT-10) based on isophorone derivatives has been designed and synthesized for the detection of formaldehyde (FA). This probe displayed an obvious ratiometric fluorescence response to FA with a blue shift from the NIR (680 nm) to the yellow light region (600 nm) in aqueous solution. And it showed good selectivity, high sensitivity and a fast response to FA (less than 5 s) due to a new recognition mechanism. Moreover, SWJT-10 has been applied to monitor FA in living cells and zebrafish.
一种基于异佛尔酮衍生物的新型比率探针（SWJT-10）已被设计并合成用于检测甲醛（FA）。该探针在水溶液中对 FA 表现出明显的比率荧光响应，从近红外（680nm）到黄光区（600nm）发生蓝移。并且由于新的识别机制，它对 FA 表现出良好的选择性、高灵敏度和快速响应（小于 5 秒）。此外，SWJT-10 已被应用于活细胞和斑马鱼中 FA 的监测。
