School of Chemistry, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
Academician Workstation, Changsha Medical University, Changsha, 410219, People's Republic of China.
Org Biomol Chem. 2023 Aug 9;21(31):6405-6409. doi: 10.1039/d3ob00888f.
Inspired by the synthetic method of benzoxazine derivatives and our previous research, a fluorescent probe (SWJT-6) was designed for formaldehyde (FA) detection based on the cyclization reaction. The synthetic SWJT-6 showed excellent colorimetric and ratiometric response to formaldehyde, and could be perfectly used as test strips to detect formaldehyde. It also showed a fast detection time (3 min), low detection limit (5.65 μM) and high selectivity for formaldehyde within various interfering analytes. In addition, SWJT-6 has been successfully applied in bioimaging of intracellular and lysosomal formaldehyde in both HeLa cells and zebrafish.
受苯并恶嗪衍生物的合成方法和我们之前的研究启发，我们设计了一种基于环化反应的荧光探针（SWJT-6）用于检测甲醛（FA）。合成的 SWJT-6 对甲醛具有出色的比色和比率响应，可完美用作检测甲醛的试条。它还具有快速的检测时间（3 分钟）、低检测限（5.65 μM）和对各种干扰分析物中的甲醛的高选择性。此外，SWJT-6 已成功应用于 HeLa 细胞和斑马鱼中细胞内和溶酶体甲醛的生物成像。
