From the Department of Pediatrics (Epstein, Biondolillo, Rizwan, Paluch) and Division of Endocrinology Diabetes and Metabolism (Ghanim, Dandona), Jacobs School of Medicine, and Biomedical Sciences, University at Buffalo, Buffalo, New York; and Addiction Recovery Research Center (Bickel), Fralin Biomedical Research Institute at Virginia Tech Carillion School of Medicine, Roanoke, Virginia.
Psychosom Med. 2023 Apr 1;85(3):289-293. doi: 10.1097/PSY.0000000000001171. Epub 2023 Jan 28.
Insulin resistance is associated with elevated activation of food reward, which should be associated with an increased reinforcing value of food. Research has also shown that sugar is a macronutrient strongly associated with reward and reinforcing value of food. This research is designed to assess whether insulin resistance is associated with a stronger preference for sugar-sweetened, thus elevating blood glucose responses in obese people with varying degrees of insulin resistance.
Thirteen people with obesity (body mass index, 39.1 kg/m 2 ; range, 30.0-45.1 kg/m 2 ) with varying degrees of insulin resistance (Homeostatic Model Assessment of Insulin Resistance, 5.2; range, 0.7-11.6) consumed novel flavored-colored yogurts that were sweetened with either sugar or monkfruit daily for 6 days to assess whether when given the choice of sugar-sweetened versus monkfruit-sweetened yogurts to consume, participants preferred sugar-sweetened yogurts.
Participants consumed a greater amount ( p = .009) and percentage ( p = .04) of sugar-sweetened yogurt earned than monkfruit-sweetened yogurt. The percent of sugar-sweetened versus monkfruit-sweetened yogurt consumed in relationship to amount earned was related to insulin resistance ( r = 0.64, p = .019), glycated hemoglobin ( r = 0.61, p = .027), insulin ( r = 0.58, p = .007), and glucose ( r = 0.56, p = .048).
Insulin resistance is associated with preference for sugar-sweetened foods in participants with obesity, which may make it hard to make dietary changes. Research is needed to assess whether treatments that improve insulin resistance also change the preference for sugar-sweetened or high-glycemic-index foods.
胰岛素抵抗与食物奖赏的激活升高有关，而食物奖赏应该与食物的增强价值有关。研究还表明，糖是一种与奖赏和食物增强价值强烈相关的宏量营养素。这项研究旨在评估胰岛素抵抗是否与对含糖甜味剂的更强偏好有关，从而提高不同程度胰岛素抵抗肥胖者的血糖反应。
13 名肥胖者（体重指数 39.1kg/m 2 ；范围 30.0-45.1kg/m 2 ），不同程度的胰岛素抵抗（稳态模型评估的胰岛素抵抗，5.2；范围 0.7-11.6），每天食用添加糖或罗汉果甜苷的新型调味彩色酸奶，以评估当提供选择含糖或罗汉果甜苷酸奶时，参与者是否更喜欢含糖酸奶。
参与者消耗的含糖酸奶量（p =.009）和百分比（p =.04）均大于罗汉果甜苷酸奶。与所获得的量相比，消耗的含糖酸奶与罗汉果甜苷酸奶的百分比与胰岛素抵抗（r = 0.64，p =.019）、糖化血红蛋白（r = 0.61，p =.027）、胰岛素（r = 0.58，p =.007）和葡萄糖（r = 0.56，p =.048）相关。
肥胖参与者的胰岛素抵抗与对含糖食物的偏好有关，这可能使其难以进行饮食改变。需要研究改善胰岛素抵抗的治疗方法是否也会改变对含糖或高血糖指数食物的偏好。
