Coloradocin, an antibiotic from a new Actinoplanes. I. Taxonomy, fermentation and biological properties.

作者信息

Jackson M, Karwowski J P, Theriault R J, Fernandes P B, Semon R C, Kohl W L

机构信息

Anti-Infective Research Division, Abbott Laboratories, North Chicago, Illinois.

出版信息

J Antibiot (Tokyo). 1987 Oct;40(10):1375-82. doi: 10.7164/antibiotics.40.1375.

Coloradocin was discovered in a screen for anti-anaerobe activity. The producing organism was determined to be a new species of Actinoplanes, designated Actinoplanes coloradoensis sp. nov. Coloradocin inhibits Bacteroides, Clostridium and other anaerobes. It does not inhibit most aerobic bacteria but is effective against Neisseria gonorrhoeae and Haemophilus influenzae. Coloradocin has low acute toxicity.