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柘树和羊栖菜提取物对C57BL/6小鼠毛发生长的影响。

Effects of Cudrania tricuspidata and Sargassum fusiforme extracts on hair growth in C57BL/6 mice.

作者信息

Rajan Priyanka, Natraj Premkumar, Kim Nak Hyoung, Kim Jae-Hoon, Choi Hyuk Joon, Han Chang-Hoon

机构信息

Department of Biochemistry, College of Veterinary Medicine, Jeju National University, Jeju, 63243, Republic of Korea.

BK Bio, Jeju, 63359, Republic of Korea.

出版信息

Lab Anim Res. 2023 Feb 17;39(1):4. doi: 10.1186/s42826-023-00154-7.

DOI:10.1186/s42826-023-00154-7
PMID:36800993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9936642/
Abstract

BACKGROUND

Cudrania tricuspidata is a perennial plant, and Sargassum fusiforme is a brown seaweed with numerous potential benefits, including anticancer, anti-inflammatory, and antioxidant activities. However, the efficacies of C. tricuspidata and S. fusiforme on hair growth have not yet been elucidated. Therefore, the present study examined the effects of C. tricuspidata and S. fusiforme extracts on hair growth in C57BL/6 mice.

RESULTS

ImageJ demonstrated that drinking and skin application of C. tricuspidata and/or S. fusiforme extracts significantly increased the hair growth rate in the dorsal skin of C57BL/6 mice compared to the control group. Histological analysis confirmed that drinking and skin application of C. tricuspidata and/or S. fusiforme extracts for 21 days significantly increased the length of hair follicles on the dorsal skin of treated C57BL/6 mice compared to that in the control mice. RNA sequencing analysis revealed that hair growth cycle-related factors (anagen factors) such as Catenin Beta 1 (Ctnnb1) and platelet-derived growth factor (Pdgf) were upregulated (> twofold) only by C. tricuspidate extracts, whereas vascular endothelial growth factor (Vegf) and Wnts were upregulated by both C. tricuspidata or S. fusiforme applications in treated mice (compared to the control mice). In addition, oncostatin M (Osm, a catagen-telogen factor) was downregulated (< 0.5 fold) by C. tricuspidata when administered via both skin and drinking mode in treated mice compared to that in control mice.

CONCLUSIONS

Our results suggest that C. tricuspidata and/or S. fusiforme extracts show potential hair growth efficacy by upregulating anagen factor genes, including β-catenin, Pdgf, Vegf, and Wnts, and downregulating catagen-telogen factor genes, including Osm, in C57BL/6 mice. The findings suggest that C. tricuspidata and/or S. fusiforme extracts are potential drug candidates to treat alopecia.

摘要

背景

柘树是一种多年生植物，而羊栖菜是一种褐藻，具有多种潜在益处，包括抗癌、抗炎和抗氧化活性。然而，柘树和羊栖菜对毛发生长的功效尚未阐明。因此，本研究考察了柘树和羊栖菜提取物对C57BL/6小鼠毛发生长的影响。

结果

ImageJ显示，与对照组相比，饮用和皮肤涂抹柘树和/或羊栖菜提取物显著提高了C57BL/6小鼠背部皮肤的毛发生长速率。组织学分析证实，与对照小鼠相比，饮用和皮肤涂抹柘树和/或羊栖菜提取物21天显著增加了经处理的C57BL/6小鼠背部皮肤毛囊的长度。RNA测序分析表明，仅柘树提取物上调了与毛发生长周期相关的因子（生长期因子），如β-连环蛋白1（Ctnnb1）和血小板衍生生长因子（Pdgf）（上调超过两倍），而在经处理的小鼠中（与对照小鼠相比），血管内皮生长因子（Vegf）和Wnts在柘树或羊栖菜处理后均上调。此外，与对照小鼠相比，在经处理的小鼠中，通过皮肤和饮用两种方式给予柘树时，制瘤素M（Osm，一种退行期-休止期因子）下调（<0.5倍）。

结论

我们的结果表明，柘树和/或羊栖菜提取物通过上调包括β-连环蛋白、Pdgf、Vegf和Wnts在内的生长期因子基因以及下调包括Osm在内的退行期-休止期因子基因，在C57BL/6小鼠中显示出潜在的毛发生长功效。这些发现表明，柘树和/或羊栖菜提取物是治疗脱发的潜在候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/5302ff403937/42826_2023_154_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/145744370466/42826_2023_154_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/cc9d8bb9191e/42826_2023_154_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/9badbaeb37fe/42826_2023_154_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/5302ff403937/42826_2023_154_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/145744370466/42826_2023_154_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/cc9d8bb9191e/42826_2023_154_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/9badbaeb37fe/42826_2023_154_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d841/9936642/5302ff403937/42826_2023_154_Fig4_HTML.jpg

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