微生物将二氧化碳和氢气转化为精细化学品羟基四氢嘧啶和四氢嘧啶。
Microbial conversion of carbon dioxide and hydrogen into the fine chemicals hydroxyectoine and ectoine.
作者信息
Cantera Sara, Di Benedetto Francesca, Tumulero Ben F, Sousa Diana Z
机构信息
Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE, Wageningen, the Netherlands.
Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE, Wageningen, the Netherlands.
出版信息
Bioresour Technol. 2023 Apr;374:128753. doi: 10.1016/j.biortech.2023.128753. Epub 2023 Feb 17.
This study explores a novel conversion of CO into the chemicals hydroxyectoine and ectoine, which are compounds with high retail values in the pharmaceutical industry. Firstly, 11 species of microbes able to use CO and H and that have the genes for ectoines synthesis (ectABCD) were identified through literature search and genomic mining. Laboratory tests were then conducted to ascertain the capacity of these microbes to produce ectoines from CO. Results showed that the most promising bacteria for CO to ectoines bioconversion areHydrogenovibrio marinus, Rhodococcus opacus, and Hydrogenibacillus schlegelii.Upon salinity and H/CO/O ratio optimization,H. marinus accumulated 85 mg of ectoine g biomass. Interestingly, R.opacusand H. schlegelii mainly produced hydroxyectoine (53 and 62 mg g biomass), which has a higher commercial value. Overall, these results constitute the first proof of a novel valorization platform of CO and lay the foundation for a new economic niche aimed at CO recircularization into pharmaceuticals.
本研究探索了一种将一氧化碳转化为化学物质羟基依克多因和依克多因的新方法，这两种化合物在制药行业具有较高的零售价值。首先，通过文献检索和基因组挖掘，确定了11种能够利用一氧化碳和氢气且具有依克多因合成基因（ectABCD）的微生物。然后进行实验室测试，以确定这些微生物从一氧化碳生产依克多因的能力。结果表明，将一氧化碳生物转化为依克多因最有前景的细菌是海生氢弧菌、不透明红球菌和施氏氢杆菌。在优化盐度和氢/一氧化碳/氧气比例后，海生氢弧菌每克生物质积累了85毫克依克多因。有趣的是，不透明红球菌和施氏氢杆菌主要产生羟基依克多因（每克生物质分别为53毫克和62毫克），其具有更高的商业价值。总体而言，这些结果首次证明了一种新的一氧化碳增值平台，并为旨在将一氧化碳循环利用于制药的新经济领域奠定了基础。
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