China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Nutrition. 2023 May;109:111969. doi: 10.1016/j.nut.2022.111969. Epub 2023 Jan 11.
Alzheimer's disease is a worldwide public health problem. However, the treatment method and treatment effects are limited. The stages of preclinical Alzheimer's disease are thought to be a better intervention period. Thus, in this review, food is given focus and the intervention stage put forward. We summarized the role of diet, nutrient supplementation, and microbioecologics in cognitive decline and found that interventions such as modified Mediterranean-ketogenic diet, nuts, vitamin B, and Bifidobacterium breve A1 are beneficial to cognition protection. Eating, rather than just taking medicine, is suggested to be an effective treatment method for older adults at risk for Alzheimer's disease.
阿尔茨海默病是一个全球性的公共卫生问题。然而,其治疗方法和治疗效果有限。目前认为,在疾病的临床前期阶段是进行干预的更好时期。因此,在这篇综述中,我们重点关注食物,并提出了干预阶段。我们总结了饮食、营养补充剂和微生物生态制剂在认知能力下降中的作用,发现改良的地中海-生酮饮食、坚果、维生素 B 和短双歧杆菌 A1 等干预措施有利于认知保护。建议将饮食作为一种有效的治疗方法,而非仅仅是药物治疗,用于预防老年人群患阿尔茨海默病。