Morinaga Milk Industry Co., Ltd Next Generation Science Institute, 5-1-83 Higashihara, Zama, Kanagawa, 252-8583, Japan.
Group for Food Functionality Assessment, Kanagawa Institute of Industrial Science and Technology, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan.
Sci Rep. 2017 Oct 18;7(1):13510. doi: 10.1038/s41598-017-13368-2.
It has previously been shown that the consumption of probiotics may have beneficial effects not only on peripheral tissues but also on the central nervous system and behavior via the microbiota-gut-brain axis, raising the possibility that treatment with probiotics could be an effective therapeutic strategy for managing neurodegenerative disorders. In this study, we investigated the effects of oral administration of Bifidobacterium breve strain A1 (B. breve A1) on behavior and physiological processes in Alzheimer's disease (AD) model mice. We found that administration of B. breve A1 to AD mice reversed the impairment of alternation behavior in a Y maze test and the reduced latency time in a passive avoidance test, indicating that it prevented cognitive dysfunction. We also demonstrated that non-viable components of the bacterium or its metabolite acetate partially ameliorated the cognitive decline observed in AD mice. Gene profiling analysis revealed that the consumption of B. breve A1 suppressed the hippocampal expressions of inflammation and immune-reactive genes that are induced by amyloid-β. Together, these findings suggest that B. breve A1 has therapeutic potential for preventing cognitive impairment in AD.
先前的研究表明，益生菌的摄入不仅对周围组织，而且通过肠道菌群-肠-脑轴对中枢神经系统和行为都可能产生有益的影响，这使得益生菌治疗可能成为管理神经退行性疾病的有效治疗策略。在这项研究中，我们研究了短双歧杆菌 A1（B. breve A1）口服给药对阿尔茨海默病（AD）模型小鼠行为和生理过程的影响。我们发现，给 AD 小鼠施用 B. breve A1 可逆转其在 Y 迷宫测试中交替行为的损伤和在被动回避测试中潜伏期的缩短，表明其可预防认知功能障碍。我们还证明了该细菌的非活性成分或其代谢产物乙酸盐部分改善了 AD 小鼠观察到的认知下降。基因谱分析显示，B. breve A1 的摄入抑制了由淀粉样蛋白-β诱导的海马炎症和免疫反应基因的表达。综上所述，这些发现表明 B. breve A1 具有预防 AD 认知障碍的治疗潜力。
