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通过磷脂囊泡融合将磷脂酰甘油掺入鼠伤寒沙门氏菌完整细胞的胞壁质脂蛋白中。

Incorporation of phosphatidylglycerol into murein lipoprotein in intact cells of Salmonella typhimurium by phospholipid vesicle fusion.

作者信息

Chattopadhyay P K, Lai J S, Wu H C

出版信息

J Bacteriol. 1979 Jan;137(1):309-12. doi: 10.1128/jb.137.1.309-312.1979.

DOI:10.1128/jb.137.1.309-312.1979
PMID:368018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218451/
Abstract

The biosynthesis of the diglyceride moiety of murein lipoprotein was studied by fusion of labeled phospholipid vesicles with intact cells of Salmonella typhimurium. Phosphatidylglycerol was found to be an excellent donor for the glyceryl moiety in lipoprotein, whereas phosphatidylethanolamine and cardiolipin were not. The incorporation of radioactivity from monoacyl-phosphatidylglycerol into lipoprotein can be attributed to its conversion to phosphatidylglycerol. The results strongly support our hypothesis that the glyceryl residue covalently linked to murein lipoprotein is derived from the nonacylated glycerol moiety of phosphatidylglycerol.

摘要

通过将标记的磷脂囊泡与鼠伤寒沙门氏菌的完整细胞融合，研究了胞壁酰脂蛋白甘油二酯部分的生物合成。发现磷脂酰甘油是脂蛋白中甘油部分的优良供体，而磷脂酰乙醇胺和心磷脂则不是。单酰磷脂酰甘油中的放射性掺入脂蛋白可归因于其转化为磷脂酰甘油。结果有力地支持了我们的假设，即与胞壁酰脂蛋白共价连接的甘油残基源自磷脂酰甘油的未酰化甘油部分。

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Incorporation of phosphatidylglycerol into murein lipoprotein in intact cells of Salmonella typhimurium by phospholipid vesicle fusion.通过磷脂囊泡融合将磷脂酰甘油掺入鼠伤寒沙门氏菌完整细胞的胞壁质脂蛋白中。
J Bacteriol. 1979 Jan;137(1):309-12. doi: 10.1128/jb.137.1.309-312.1979.
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本文引用的文献

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Enzymes of phospholipid metabolism: localization in the cytoplasmic and outer membrane of the cell envelope of Escherichia coli and Salmonella typhimurium.磷脂代谢酶：在大肠杆菌和鼠伤寒沙门氏菌细胞包膜的细胞质膜和外膜中的定位
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Distribution of phospholipid-synthesizing enzymes in the wall and membrane subfractions of the envelope of Escherichia coli.磷脂合成酶在大肠杆菌包膜壁和膜亚组分中的分布
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Acyl phosphatidylglycerol. A new phospholipid from Salmonella typhimurium.酰基磷脂酰甘油。一种来自鼠伤寒沙门氏菌的新型磷脂。
J Biol Chem. 1971 May 25;246(10):3305-13.
5
Chemical characterization, spatial distribution and function of a lipoprotein (murein-lipoprotein) of the E. coli cell wall. The specific effect of trypsin on the membrane structure.大肠杆菌细胞壁脂蛋白（胞壁酰脂蛋白）的化学特性、空间分布及功能。胰蛋白酶对膜结构的特定作用。
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6
Two forms of a structural lipoprotein in the envelope of Escherichia coli. Further characterization of the free form.大肠杆菌包膜中一种结构脂蛋白的两种形式。游离形式的进一步表征。
J Biol Chem. 1973 Aug 25;248(16):5654-9.
7
Covalent binding of lipid to protein. Diglyceride and amide-linked fatty acid at the N-terminal end of the murein-lipoprotein of the Escherichia coli outer membrane.脂质与蛋白质的共价结合。大肠杆菌外膜胞壁质脂蛋白N端的甘油二酯和酰胺连接的脂肪酸。
Eur J Biochem. 1973 Apr;34(2):284-96. doi: 10.1111/j.1432-1033.1973.tb02757.x.
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Mechanism of the enzymatic synthesis of cardiolipin in Escherichia coli.大肠杆菌中心磷脂酶促合成的机制。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):648-51. doi: 10.1073/pnas.69.3.648.
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Phospholipid metabolism during bacterial growth.细菌生长过程中的磷脂代谢。
J Lipid Res. 1969 Mar;10(2):220-33.
10
Identification of sn-glycero-1-phosphate and phosphoethanolamine residues linked to the membrane-derived Oligosaccharides of Escherichia coli.鉴定与大肠杆菌膜衍生寡糖相连的sn-甘油-1-磷酸和磷酸乙醇胺残基。
J Biol Chem. 1976 Jul 25;251(14):4208-13.